VTA dopamine neuron (Tarfa, Evans, and Khaliq 2017)

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Accession:226254
In our model of a midbrain VTA dopamine neuron, we show that the decay kinetics of the A-type potassium current can control the timing of rebound action potentials.
Reference:
1 . Tarfa RA, Evans RC, Khaliq ZM (2017) Enhanced Sensitivity to Hyperpolarizing Inhibition in Mesoaccumbal Relative to Nigrostriatal Dopamine Neuron Subpopulations. J Neurosci 37:3311-3330 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Basal ganglia;
Cell Type(s): Ventral tegmental area dopamine neuron;
Channel(s): I A; I A, slow; I K,Ca; I Calcium; I Na, leak; I Na,t; I T low threshold; I L high threshold; I h; I K; I N; I R;
Gap Junctions:
Receptor(s): GabaA; AMPA; NMDA;
Gene(s):
Transmitter(s): Gaba;
Simulation Environment: GENESIS;
Model Concept(s): Ion Channel Kinetics; Action Potentials; Activity Patterns;
Implementer(s): Evans, Rebekah [Rebekah.Evans at nih.gov];
Search NeuronDB for information about:  GabaA; AMPA; NMDA; I Na,t; I L high threshold; I N; I T low threshold; I A; I K; I h; I K,Ca; I Calcium; I A, slow; I R; I Na, leak; Gaba; 

*relative
*cartesian
*asymmetric
*lambda_warn


*set_global ELEAK {ELEAK}
*set_global RM {RM}
*set_global RA {RA}
*set_global CM {CM}
*set_global EREST_ACT {EREST_ACT}


*start_cell
	
*spherical

soma none 25 0 0 25

*cylindrical

primdend1_1 soma 20 0 0 2.5
primdend1_2 . 20 0 0 2.5
primdend1_3 . 20 0 0 2
primdend1_4 . 20 0 0 2

primdend2_1 soma 20 0 0 2.5
primdend2_2 . 20 0 0 2.5
primdend2_3 . 20 0 0 2
primdend2_4 . 20 0 0 2
	
secdend11 primdend1_4 20 0 0 1
secdend12 primdend1_4 20 0 0 1
secdend21 primdend2_4 -20 0 0 1
secdend22 primdend2_4 -20 0 0 1

tertdend1_1 secdend11 20  0  0  0.8
tertdend1_2 . 20 0 0 0.8 
tertdend1_3 . 20 0 0 0.8
tertdend1_4 . 20 0 0 0.8
tertdend1_5 . 20 0 0 0.8
tertdend1_6 . 20 0 0 0.8
tertdend1_7 . 20 0 0 0.8

tertdend2_1 secdend11 20  -10  0  0.8
tertdend2_2 . 20 0 0 0.8
tertdend2_3 . 20 0 0 0.8
tertdend2_4 . 20 0 0 0.8
tertdend2_5 . 20 0 0 0.8
tertdend2_6 . 20 0 0 0.8
tertdend2_7 . 20 0 0 0.8

tertdend3_1 secdend12 20  10  0  0.8
tertdend3_2 . 20 0 0 0.8 
tertdend3_3 . 20 0 0 0.8
tertdend3_4 . 20 0 0 0.8
tertdend3_5 . 20 0 0 0.8
tertdend3_6 . 20 0 0 0.8
tertdend3_7 . 20 0 0 0.8 
   
tertdend4_1 secdend12 20  -10  0  0.8
tertdend4_2 . 20 0 0 0.8 
tertdend4_3 . 20 0 0 0.8
tertdend4_4 . 20 0 0 0.8
tertdend4_5 . 20 0 0 0.8
tertdend4_6 . 20 0 0 0.8
tertdend4_7 . 20 0 0 0.8 
   
tertdend5_1 secdend21 -20  10  0  0.8
tertdend5_2 . 20 0 0 0.8 
tertdend5_3 . 20 0 0 0.8
tertdend5_4 . 20 0 0 0.8
tertdend5_5 . 20 0 0 0.8
tertdend5_6 . 20 0 0 0.8
tertdend5_7 . 20 0 0 0.8 
   
tertdend6_1 secdend21 -20  -10  0  0.8
tertdend6_2 . 20 0 0 0.8 
tertdend6_3 . 20 0 0 0.8
tertdend6_4 . 20 0 0 0.8
tertdend6_5 . 20 0 0 0.8
tertdend6_6 . 20 0 0 0.8
tertdend6_7 . 20 0 0 0.8 
   
tertdend7_1 secdend22 -20  10  0  0.8
tertdend7_2 . 20 0 0 0.8 
tertdend7_3 . 20 0 0 0.8
tertdend7_4 . 20 0 0 0.8
tertdend7_5 . 20 0 0 0.8
tertdend7_6 . 20 0 0 0.8
tertdend7_7 . 20 0 0 0.8
   
tertdend8_1 secdend22 -20  -10  0  0.8
tertdend8_2 . 20 0 0 0.8 
tertdend8_3 . 20 0 0 0.8
tertdend8_4 . 20 0 0 0.8
tertdend8_5 . 20 0 0 0.8
tertdend8_6 . 20 0 0 0.8
tertdend8_7 . 20 0 0 0.8

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