Discrimination on behavioral time-scales mediated by reaction-diffusion in dendrites (Bhalla 2017)

 Download zip file 
Help downloading and running models
Accession:227318
Sequences of events are ubiquitous in sensory, motor, and cognitive function. Key computational operations, including pattern recognition, event prediction, and plasticity, involve neural discrimination of spatio-temporal sequences. Here we show that synaptically-driven reaction diffusion pathways on dendrites can perform sequence discrimination on behaviorally relevant time-scales. We used abstract signaling models to show that selectivity arises when inputs at successive locations are aligned with, and amplified by, propagating chemical waves triggered by previous inputs. We incorporated biological detail using sequential synaptic input onto spines in morphologically, electrically, and chemically detailed pyramidal neuronal models based on rat data.
Reference:
1 . Bhalla US (2017) Synaptic input sequence discrimination on behavioral time-scales mediated by reaction-diffusion chemistry in dendrites. Elife [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Synapse; Dendrite; Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Hippocampus;
Cell Type(s): Hippocampus CA1 pyramidal cell;
Channel(s): I A; I Na,t; I L high threshold;
Gap Junctions:
Receptor(s): AMPA; NMDA;
Gene(s): Nav1.7 SCN9A;
Transmitter(s):
Simulation Environment: MOOSE/PyMOOSE;
Model Concept(s): Pattern Recognition; Reaction-diffusion; Synaptic Plasticity; Signaling pathways; Calcium dynamics;
Implementer(s): Bhalla, Upinder S [bhalla at ncbs.res.in];
Search NeuronDB for information about:  Hippocampus CA1 pyramidal cell; AMPA; NMDA; I Na,t; I L high threshold; I A;
Loading data, please wait...