Cerebellar granular layer (Maex and De Schutter 1998)

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Circuit model of the granular layer representing a one-dimensional array of single-compartmental granule cells (grcs) and Golgi cells (Gocs). This paper examines the effects of feedback inhibition (grc -> Goc -> grc) versus feedforward inhibition (mossy fibre -> Goc -> grc) on synchronization and oscillatory behaviour.
1 . Maex R, De Schutter E (1998) Synchronization of golgi and granule cell firing in a detailed network model of the cerebellar granule cell layer. J Neurophysiol 80:2521-37 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism: Cerebellum;
Cell Type(s): Cerebellum interneuron granule cell; Cerebellum golgi cell;
Channel(s): I Na,t; I A; I h; I K,Ca; I L high threshold; I_KD;
Gap Junctions:
Receptor(s): AMPA; GabaA; NMDA;
Transmitter(s): Gaba; Glutamate;
Simulation Environment: GENESIS;
Model Concept(s): Synchronization; Oscillations;
Implementer(s): Maex, Reinoud [reinoud at bbf.uia.ac.be];
Search NeuronDB for information about:  Cerebellum interneuron granule cell; GabaA; AMPA; NMDA; I Na,t; I L high threshold; I A; I h; I K,Ca; I_KD; Gaba; Glutamate;
This package contains the Genesis-code for the simulations in

Maex R, De Schutter E (1998)
Synchronization of Golgi and granule cell firing in a detailed 
network model of the cerebellar granule cell layer.
J. Neurophysiol. 80, 2521-2537.

For more info, please consult R. Maex at

Each subdirectory contains an executable Genesis script. 
The following model implementations are available.

Granule_cell : contains the scripts describing a single-compartmental
granule cell.  Allows for the computation of responses to current
injection and to synaptic stimulation, by running the executable TEST.g.

Golgi_cell : same as Granule_cell, but for a single-compartmental
Golgi cell.

Gran_layer_1D : describes a one-dimensional (parallel fiber axis)
segment of the cerebellar granular layer, containing mossy fibers,
granule and Golgi cells.  Mossy fibers are random spike generators.
Granule and Golgi cells are the single-compartmental neurons
implemented in the Granule_cell and Golgi_cell directories described
above. The densities of neurons and synapses, the synaptic
strengths/delays and their randomization intervals, and the patterns
of mossy fiber activity are variable parameters.

The code has been run on Sun Solaris, and Mac X Linux.
The channel tables are included. In case of incompatibility,
they can be recreated by uncommenting the TABSAVE comments in
Granule_cell/TEST.g and Golgi_cell/TEST.g.

16Mar2005 fixed bug in h channel (missing brackets around argument of exp}
(see Granule_cell/Gran_chan.g and Golgi_cell/Golg_chan.g)

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