Nicotinic control of dopamine release in nucleus accumbens (Maex et al. 2014)

 Download zip file 
Help downloading and running models
Accession:228337
Minimal model of the VTA (ventral segmental area) representing two (GABA versus dopamine) neuron populations and two subtypes of nicotinic receptors (alpha4beta2 versus alpha7). The model is used to tell apart circuit from receptor mechanisms in the nicotinic control of dopamine release and its pharmacological manipulation.
Reference:
1 . Maex R, Grinevich VP, Grinevich V, Budygin E, Bencherif M, Gutkin B (2014) Understanding the role a7 nicotinic receptors play in dopamine efflux in nucleus accumbens. ACS Chem Neurosci 5:1032-40 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neural mass; Channel/Receptor;
Brain Region(s)/Organism: Basal ganglia;
Cell Type(s): Ventral tegmental area dopamine neuron;
Channel(s):
Gap Junctions:
Receptor(s): Nicotinic;
Gene(s):
Transmitter(s): Acetylcholine; Dopamine; Gaba; Glutamate;
Simulation Environment: XPP;
Model Concept(s): Schizophrenia; Addiction; Volume transmission; Neuromodulation; Pathophysiology; Rate-coding model neurons; Simplified Models;
Implementer(s): Maex, Reinoud [reinoud at bbf.uia.ac.be];
Search NeuronDB for information about:  Nicotinic; Acetylcholine; Dopamine; Gaba; Glutamate;
/
MaexEtAl2014
Fig2
Fig3
Fig6
FigS4
FigS5
README
                            
This package contains the XPP scripts used to make the figures in

Maex R, Grinevich VP, Grinevich V, Budygin E, Bencherif M, Gutkin B (2014)
Understanding the role a7 nicotinic receptors play in dopamine efflux
in nucleus accumbens. ACS Chemical Neuroscience 5, 1032-1040.

More particularly, there are separate scripts for Figures 2B, 3B and 6, and
for the panels of supplementary Figures S4 and S5.

(Other figures did plot experimental data, or steady-state functions
which can easily be recovered from the scripts.
Some traces of other figures can also be recovered, for instance
the traces of Fig. 4B,C are also covered in Fig. S4C.)

The above paper presents voltammetric recordings of dopamine responses, 
along with a minimal model explaining the nicotinic control of 
dopamine efflux in nucleus accumbens.

This minimal model, implemented in XPP, was built to tell apart response components 
generated by circuit mechanisms from response characteristics caused by 
activation or desensitization of the receptors embedded in the circuit.
In brief, the model consists of two neuron types (GABA and dopamine producing)
and two nicotinic receptor subtypes (a7 and a4b2).
The two populations are just implemented as leaky integrators, the
receptor subtypes as two-gate (activation and desensitization) channels.
The two receptor subtypes have very different concentration- and time-dependencies.
By varying their relative expression on GABA versus dopamine producing neurons,  
qualitatively strongly different responses can be generated.


The scripts are based on a previous model described in greater detail in
Graupner M, Maex R, Gutkin B (2013)
Endogenous cholinergic inputs and local circuit mechanisms govern 
the phasic mesolimbic dopamine response to nicotine.
PLoS Comput Biol. 2013;9(8):e1003183. doi: 10.1371/journal.pcbi.1003183.

Loading data, please wait...