" ... We show that during seizure large-scale neural populations spanning centimetres of cortex coordinate with small neural groups spanning cortical columns, and provide evidence that rapidly propagating waves of activity underlie this increased inter-scale coupling. We develop a corresponding computational model to propose specific mechanisms—namely, the effects of an increased extracellular potassium concentration diffusing in space—that support the observed spatiotemporal dynamics. Understanding the multi-scale, spatiotemporal dynamics of human seizures—and connecting these dynamics to specific biological mechanisms—promises new insights to treat this devastating disease.
Martinet LE, Fiddyment G, Madsen JR, Eskandar EN, Truccolo W, Eden UT, Cash SS, Kramer MA (2017) Human seizures couple across spatial scales through travelling wave dynamics. Nat Commun 8:14896 [PubMed]