Model for concentration invariant odor coding based on primacy hypothesis (Wilson et al 2017)

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Accession:231814
"... Here we propose that, in olfaction, a small and relatively stable set comprised of the earliest activated receptors forms a code for concentration-invariant odor identity. One prediction of this “primacy coding” scheme is that decisions based on odor identity can be made solely using early odor-evoked neural activity. Using an optogenetic masking paradigm, we define the sensory integration time necessary for odor identification and demonstrate that animals can use information occurring <100ms after inhalation onset to identify odors. ... We propose a computational model demonstrating how such a code can be read by neural circuits of the olfactory system."
Reference:
1 . Wilson CD, Serrano GO, Koulakov AA, Rinberg D (2017) A primacy code for odor identity Nature Communications 8(1):1477 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Mouse;
Cell Type(s): Olfactory bulb main mitral cell;
Channel(s):
Gap Junctions:
Receptor(s): Gaseous Receptors;
Gene(s):
Transmitter(s): Gaba;
Simulation Environment: MATLAB;
Model Concept(s): Activity Patterns; Olfaction;
Implementer(s): Koulakov, Alexei [akula at cshl.edu];
Search NeuronDB for information about:  Olfactory bulb main mitral cell; Gaseous Receptors; Gaba;
 
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