Models of the neuron, planar (GPµE) and mushroom-shaped (GMµE) microelectrodes, neuro-electronic junction (microelectrode-electrolyte interface, cleft effect, and protein-glycocalyx electric double layer) are presented. Then, neuronal electrical activity is simulated by HSPICE software, and analyzed as a function of the most sensitive biophysical models parameters such as the neuron-microelectrode cleft width, spreading and seal resistances, ion-channel densities, double-layer properties, and microelectrode geometries.
Reference:
1 .
Massobrio G, Martinoia S, Massobrio P (2018) Equivalent Circuit of the Neuro-Electronic Junction for Signal Recordings From Planar and Engulfed Micro-Nano-Electrodes. IEEE Trans Biomed Circuits Syst 12:3-12 [PubMed]
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