Model of the cerebellar granular network (Sudhakar et al 2017)

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Accession:232023
"The granular layer, which mainly consists of granule and Golgi cells, is the first stage of the cerebellar cortex and processes spatiotemporal information transmitted by mossy fiber inputs with a wide variety of firing patterns. To study its dynamics at multiple time scales in response to inputs approximating real spatiotemporal patterns, we constructed a large-scale 3D network model of the granular layer. ..."
Reference:
1 . Sudhakar SK, Hong S, Raikov I, Publio R, Lang C, Close T, Guo D, Negrello M, De Schutter E (2017) Spatiotemporal network coding of physiological mossy fiber inputs by the cerebellar granular layer. PLoS Comput Biol 13:e1005754 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism: Cerebellum;
Cell Type(s): Cerebellum golgi cell;
Channel(s): I A; I Calcium; I K; I K,Ca; I Na,t; I h; I Na,p; I T low threshold;
Gap Junctions: Gap junctions;
Receptor(s): AMPA; NMDA; Gaba;
Gene(s):
Transmitter(s): Glutamate; Gaba;
Simulation Environment: NEURON;
Model Concept(s): Spatio-temporal Activity Patterns; Oscillations; Synchronization; Winner-take-all;
Implementer(s): Hong, Sungho [shhong at oist.jp]; Guo, Daqing [dqguo at uestc.edu.cn]; Raikov, Ivan [ivan.g.raikov at gmail.com]; Publio, Rodrigo [publio at oist.jp]; De Schutter, Erik [erik at oist.jp];
Search NeuronDB for information about:  AMPA; NMDA; Gaba; I Na,p; I Na,t; I T low threshold; I A; I K; I h; I K,Ca; I Calcium; Gaba; Glutamate;
// Template for a cerebellar mossy fiber
//
// Written by Ivan Raikov, Shyam Kumar Sudhakar, and Sungho Hong
// Computational Neuroscience Unit, Okinawa Institute of Science and Technology, Japan
// Supervisor: Erik De Schutter
//
// Correspondence: Sungho Hong (shhong@oist.jp)
//
// September 16, 2017

begintemplate Mossytemp

public vs,spiketime,connect2target
external flag_vecstim
objref vs,spiketime,r

proc init() {

  //vec=$1
  spiketime=new Vector()
  if (flag_vecstim ==1) {
  vec = $1
    if (vec == 0) {	// if inactive
      vs = new NetStim()
      vs.number = 0
      vs.interval =7
      vs.start = 8
    } else{
//      print "vecstim\n"
      vs = new VecStim() //if active
    }
  } else {
      r = new Random($1)
      print "netstim\n"
      vs = new NetStim()
      vs.number   = 0//1e9
      vs.interval = 100
      vs.noise = r.uniform(0.3,1)
      vs.start = 0
      }


}

obfunc connect2target() {localobj nc // $o1 target point process, optinal $o2 returned Netcon
    nc = new NetCon(vs,$o1)
    nc.record(spiketime)
    if (numarg()==2) {$o2 = nc} // for backward compatibility
  return nc
}

endtemplate Mossytemp


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