A unified thalamic model of multiple distinct oscillations (Li, Henriquez and Fröhlich 2017)

 Download zip file 
Help downloading and running models
Accession:233509
We present a unified model of the thalamus that is capable of independently generating multiple distinct oscillations (delta, spindle, alpha and gamma oscillations) under different levels of acetylcholine (ACh) and norepinephrine (NE) modulation corresponding to different physiological conditions (deep sleep, light sleep, relaxed wakefulness and attention). The model also shows that entrainment of thalamic oscillations is state-dependent.
Reference:
1 . Li G, Henriquez C, Fröhlich F (2017) Unified Thalamic Model Generates Multiple Distinct Oscillations with State-dependent Entrainment by Stimulation PLOS Computational Biology 13(10):e1005797
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism: Thalamus;
Cell Type(s): Thalamus geniculate nucleus/lateral principal neuron; Thalamus reticular nucleus cell; Thalamus lateral geniculate nucleus interneuron;
Channel(s): I Na,t; I K; I h; I L high threshold; I T low threshold; I_AHP; I CAN; I K,leak;
Gap Junctions: Gap junctions;
Receptor(s): AMPA; NMDA; GabaA;
Gene(s):
Transmitter(s): Acetylcholine; Norephinephrine;
Simulation Environment: C or C++ program;
Model Concept(s): Sleep; Activity Patterns; Gamma oscillations; Oscillations; Brain Rhythms;
Implementer(s): Li, Guoshi [guoshi_li at med.unc.edu];
Search NeuronDB for information about:  Thalamus geniculate nucleus/lateral principal neuron; Thalamus reticular nucleus cell; GabaA; AMPA; NMDA; I Na,t; I L high threshold; I T low threshold; I K; I K,leak; I h; I CAN; I_AHP; Acetylcholine; Norephinephrine;
<?xml version="1.0" encoding="UTF-8" standalone="no"?>
<?fileVersion 4.0.0?><cproject storage_type_id="org.eclipse.cdt.core.XmlProjectDescriptionStorage">
	<storageModule moduleId="org.eclipse.cdt.core.settings">
		<cconfiguration id="cdt.managedbuild.config.gnu.cross.exe.debug.1118754129">
			<storageModule buildSystemId="org.eclipse.cdt.managedbuilder.core.configurationDataProvider" id="cdt.managedbuild.config.gnu.cross.exe.debug.1118754129" moduleId="org.eclipse.cdt.core.settings" name="Debug">
				<externalSettings/>
				<extensions>
					<extension id="org.eclipse.cdt.core.GmakeErrorParser" point="org.eclipse.cdt.core.ErrorParser"/>
					<extension id="org.eclipse.cdt.core.CWDLocator" point="org.eclipse.cdt.core.ErrorParser"/>
					<extension id="org.eclipse.cdt.core.GCCErrorParser" point="org.eclipse.cdt.core.ErrorParser"/>
					<extension id="org.eclipse.cdt.core.GASErrorParser" point="org.eclipse.cdt.core.ErrorParser"/>
					<extension id="org.eclipse.cdt.core.GLDErrorParser" point="org.eclipse.cdt.core.ErrorParser"/>
					<extension id="org.eclipse.cdt.core.ELF" point="org.eclipse.cdt.core.BinaryParser"/>
				</extensions>
			</storageModule>
			<storageModule moduleId="cdtBuildSystem" version="4.0.0">
				<configuration artifactName="${ProjName}" buildArtefactType="org.eclipse.cdt.build.core.buildArtefactType.exe" buildProperties="org.eclipse.cdt.build.core.buildType=org.eclipse.cdt.build.core.buildType.debug,org.eclipse.cdt.build.core.buildArtefactType=org.eclipse.cdt.build.core.buildArtefactType.exe" cleanCommand="rm -rf" description="" id="cdt.managedbuild.config.gnu.cross.exe.debug.1118754129" name="Debug" parent="cdt.managedbuild.config.gnu.cross.exe.debug">
					<folderInfo id="cdt.managedbuild.config.gnu.cross.exe.debug.1118754129." name="/" resourcePath="">
						<toolChain id="cdt.managedbuild.toolchain.gnu.cross.exe.debug.2099992086" name="Cross GCC" superClass="cdt.managedbuild.toolchain.gnu.cross.exe.debug">
							<targetPlatform archList="all" binaryParser="org.eclipse.cdt.core.ELF" id="cdt.managedbuild.targetPlatform.gnu.cross.1111136765" isAbstract="false" osList="all" superClass="cdt.managedbuild.targetPlatform.gnu.cross"/>
							<builder buildPath="${workspace_loc:/ThalamicOSC}/Debug" id="cdt.managedbuild.builder.gnu.cross.310981435" managedBuildOn="true" name="Gnu Make Builder.Debug" superClass="cdt.managedbuild.builder.gnu.cross"/>
							<tool id="cdt.managedbuild.tool.gnu.cross.c.compiler.519015158" name="Cross GCC Compiler" superClass="cdt.managedbuild.tool.gnu.cross.c.compiler">
								<option defaultValue="gnu.c.optimization.level.none" id="gnu.c.compiler.option.optimization.level.348553891" superClass="gnu.c.compiler.option.optimization.level" valueType="enumerated"/>
								<option id="gnu.c.compiler.option.debugging.level.1366332237" superClass="gnu.c.compiler.option.debugging.level" value="gnu.c.debugging.level.max" valueType="enumerated"/>
								<inputType id="cdt.managedbuild.tool.gnu.c.compiler.input.612741794" superClass="cdt.managedbuild.tool.gnu.c.compiler.input"/>
							</tool>
							<tool id="cdt.managedbuild.tool.gnu.cross.cpp.compiler.2090960261" name="Cross G++ Compiler" superClass="cdt.managedbuild.tool.gnu.cross.cpp.compiler">
								<option id="gnu.cpp.compiler.option.optimization.level.931720093" superClass="gnu.cpp.compiler.option.optimization.level" value="gnu.cpp.compiler.optimization.level.none" valueType="enumerated"/>
								<option id="gnu.cpp.compiler.option.debugging.level.1341608717" superClass="gnu.cpp.compiler.option.debugging.level" value="gnu.cpp.compiler.debugging.level.max" valueType="enumerated"/>
								<inputType id="cdt.managedbuild.tool.gnu.cpp.compiler.input.1772361338" superClass="cdt.managedbuild.tool.gnu.cpp.compiler.input"/>
							</tool>
							<tool id="cdt.managedbuild.tool.gnu.cross.c.linker.1091721079" name="Cross GCC Linker" superClass="cdt.managedbuild.tool.gnu.cross.c.linker"/>
							<tool id="cdt.managedbuild.tool.gnu.cross.cpp.linker.1901840247" name="Cross G++ Linker" superClass="cdt.managedbuild.tool.gnu.cross.cpp.linker">
								<inputType id="cdt.managedbuild.tool.gnu.cpp.linker.input.1097539609" superClass="cdt.managedbuild.tool.gnu.cpp.linker.input">
									<additionalInput kind="additionalinputdependency" paths="$(USER_OBJS)"/>
									<additionalInput kind="additionalinput" paths="$(LIBS)"/>
								</inputType>
							</tool>
							<tool id="cdt.managedbuild.tool.gnu.cross.archiver.93718675" name="Cross GCC Archiver" superClass="cdt.managedbuild.tool.gnu.cross.archiver"/>
							<tool id="cdt.managedbuild.tool.gnu.cross.assembler.976669499" name="Cross GCC Assembler" superClass="cdt.managedbuild.tool.gnu.cross.assembler">
								<inputType id="cdt.managedbuild.tool.gnu.assembler.input.1441417023" superClass="cdt.managedbuild.tool.gnu.assembler.input"/>
							</tool>
						</toolChain>
					</folderInfo>
				</configuration>
			</storageModule>
			<storageModule moduleId="org.eclipse.cdt.core.externalSettings"/>
		</cconfiguration>
		<cconfiguration id="cdt.managedbuild.config.gnu.cross.exe.release.1145240651">
			<storageModule buildSystemId="org.eclipse.cdt.managedbuilder.core.configurationDataProvider" id="cdt.managedbuild.config.gnu.cross.exe.release.1145240651" moduleId="org.eclipse.cdt.core.settings" name="Release">
				<externalSettings/>
				<extensions>
					<extension id="org.eclipse.cdt.core.GmakeErrorParser" point="org.eclipse.cdt.core.ErrorParser"/>
					<extension id="org.eclipse.cdt.core.CWDLocator" point="org.eclipse.cdt.core.ErrorParser"/>
					<extension id="org.eclipse.cdt.core.GCCErrorParser" point="org.eclipse.cdt.core.ErrorParser"/>
					<extension id="org.eclipse.cdt.core.GASErrorParser" point="org.eclipse.cdt.core.ErrorParser"/>
					<extension id="org.eclipse.cdt.core.GLDErrorParser" point="org.eclipse.cdt.core.ErrorParser"/>
					<extension id="org.eclipse.cdt.core.ELF" point="org.eclipse.cdt.core.BinaryParser"/>
				</extensions>
			</storageModule>
			<storageModule moduleId="cdtBuildSystem" version="4.0.0">
				<configuration artifactName="${ProjName}" buildArtefactType="org.eclipse.cdt.build.core.buildArtefactType.exe" buildProperties="org.eclipse.cdt.build.core.buildType=org.eclipse.cdt.build.core.buildType.release,org.eclipse.cdt.build.core.buildArtefactType=org.eclipse.cdt.build.core.buildArtefactType.exe" cleanCommand="rm -rf" description="" id="cdt.managedbuild.config.gnu.cross.exe.release.1145240651" name="Release" parent="cdt.managedbuild.config.gnu.cross.exe.release">
					<folderInfo id="cdt.managedbuild.config.gnu.cross.exe.release.1145240651." name="/" resourcePath="">
						<toolChain id="cdt.managedbuild.toolchain.gnu.cross.exe.release.1177644843" name="Cross GCC" superClass="cdt.managedbuild.toolchain.gnu.cross.exe.release">
							<targetPlatform archList="all" binaryParser="org.eclipse.cdt.core.ELF" id="cdt.managedbuild.targetPlatform.gnu.cross.258053468" isAbstract="false" osList="all" superClass="cdt.managedbuild.targetPlatform.gnu.cross"/>
							<builder buildPath="${workspace_loc:/ThalamicOSC}/Release" id="cdt.managedbuild.builder.gnu.cross.1851021965" managedBuildOn="true" name="Gnu Make Builder.Release" superClass="cdt.managedbuild.builder.gnu.cross"/>
							<tool id="cdt.managedbuild.tool.gnu.cross.c.compiler.1315269615" name="Cross GCC Compiler" superClass="cdt.managedbuild.tool.gnu.cross.c.compiler">
								<option defaultValue="gnu.c.optimization.level.most" id="gnu.c.compiler.option.optimization.level.1209952364" superClass="gnu.c.compiler.option.optimization.level" valueType="enumerated"/>
								<option id="gnu.c.compiler.option.debugging.level.1864440203" superClass="gnu.c.compiler.option.debugging.level" value="gnu.c.debugging.level.none" valueType="enumerated"/>
								<inputType id="cdt.managedbuild.tool.gnu.c.compiler.input.1757073930" superClass="cdt.managedbuild.tool.gnu.c.compiler.input"/>
							</tool>
							<tool id="cdt.managedbuild.tool.gnu.cross.cpp.compiler.1400885606" name="Cross G++ Compiler" superClass="cdt.managedbuild.tool.gnu.cross.cpp.compiler">
								<option id="gnu.cpp.compiler.option.optimization.level.962221307" superClass="gnu.cpp.compiler.option.optimization.level" value="gnu.cpp.compiler.optimization.level.most" valueType="enumerated"/>
								<option id="gnu.cpp.compiler.option.debugging.level.1084898822" superClass="gnu.cpp.compiler.option.debugging.level" value="gnu.cpp.compiler.debugging.level.none" valueType="enumerated"/>
								<inputType id="cdt.managedbuild.tool.gnu.cpp.compiler.input.1093861705" superClass="cdt.managedbuild.tool.gnu.cpp.compiler.input"/>
							</tool>
							<tool id="cdt.managedbuild.tool.gnu.cross.c.linker.75234707" name="Cross GCC Linker" superClass="cdt.managedbuild.tool.gnu.cross.c.linker"/>
							<tool id="cdt.managedbuild.tool.gnu.cross.cpp.linker.66417281" name="Cross G++ Linker" superClass="cdt.managedbuild.tool.gnu.cross.cpp.linker">
								<inputType id="cdt.managedbuild.tool.gnu.cpp.linker.input.1490491684" superClass="cdt.managedbuild.tool.gnu.cpp.linker.input">
									<additionalInput kind="additionalinputdependency" paths="$(USER_OBJS)"/>
									<additionalInput kind="additionalinput" paths="$(LIBS)"/>
								</inputType>
							</tool>
							<tool id="cdt.managedbuild.tool.gnu.cross.archiver.1100069439" name="Cross GCC Archiver" superClass="cdt.managedbuild.tool.gnu.cross.archiver"/>
							<tool id="cdt.managedbuild.tool.gnu.cross.assembler.852018819" name="Cross GCC Assembler" superClass="cdt.managedbuild.tool.gnu.cross.assembler">
								<inputType id="cdt.managedbuild.tool.gnu.assembler.input.1560172365" superClass="cdt.managedbuild.tool.gnu.assembler.input"/>
							</tool>
						</toolChain>
					</folderInfo>
				</configuration>
			</storageModule>
			<storageModule moduleId="org.eclipse.cdt.core.externalSettings"/>
		</cconfiguration>
	</storageModule>
	<storageModule moduleId="cdtBuildSystem" version="4.0.0">
		<project id="ThalamicOSC.cdt.managedbuild.target.gnu.cross.exe.943795334" name="Executable" projectType="cdt.managedbuild.target.gnu.cross.exe"/>
	</storageModule>
	<storageModule moduleId="scannerConfiguration">
		<autodiscovery enabled="true" problemReportingEnabled="true" selectedProfileId=""/>
		<scannerConfigBuildInfo instanceId="cdt.managedbuild.config.gnu.cross.exe.debug.1118754129;cdt.managedbuild.config.gnu.cross.exe.debug.1118754129.;cdt.managedbuild.tool.gnu.cross.c.compiler.519015158;cdt.managedbuild.tool.gnu.c.compiler.input.612741794">
			<autodiscovery enabled="true" problemReportingEnabled="true" selectedProfileId="org.eclipse.cdt.managedbuilder.core.GCCManagedMakePerProjectProfileC"/>
		</scannerConfigBuildInfo>
		<scannerConfigBuildInfo instanceId="cdt.managedbuild.config.gnu.cross.exe.release.1145240651;cdt.managedbuild.config.gnu.cross.exe.release.1145240651.;cdt.managedbuild.tool.gnu.cross.cpp.compiler.1400885606;cdt.managedbuild.tool.gnu.cpp.compiler.input.1093861705">
			<autodiscovery enabled="true" problemReportingEnabled="true" selectedProfileId="org.eclipse.cdt.managedbuilder.core.GCCManagedMakePerProjectProfileCPP"/>
		</scannerConfigBuildInfo>
		<scannerConfigBuildInfo instanceId="cdt.managedbuild.config.gnu.cross.exe.release.1145240651;cdt.managedbuild.config.gnu.cross.exe.release.1145240651.;cdt.managedbuild.tool.gnu.cross.c.compiler.1315269615;cdt.managedbuild.tool.gnu.c.compiler.input.1757073930">
			<autodiscovery enabled="true" problemReportingEnabled="true" selectedProfileId="org.eclipse.cdt.managedbuilder.core.GCCManagedMakePerProjectProfileC"/>
		</scannerConfigBuildInfo>
		<scannerConfigBuildInfo instanceId="cdt.managedbuild.config.gnu.cross.exe.debug.1118754129;cdt.managedbuild.config.gnu.cross.exe.debug.1118754129.;cdt.managedbuild.tool.gnu.cross.cpp.compiler.2090960261;cdt.managedbuild.tool.gnu.cpp.compiler.input.1772361338">
			<autodiscovery enabled="true" problemReportingEnabled="true" selectedProfileId="org.eclipse.cdt.managedbuilder.core.GCCManagedMakePerProjectProfileCPP"/>
		</scannerConfigBuildInfo>
	</storageModule>
	<storageModule moduleId="org.eclipse.cdt.core.LanguageSettingsProviders"/>
</cproject>

Loading data, please wait...