A unified thalamic model of multiple distinct oscillations (Li, Henriquez and Fröhlich 2017)

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Accession:233509
We present a unified model of the thalamus that is capable of independently generating multiple distinct oscillations (delta, spindle, alpha and gamma oscillations) under different levels of acetylcholine (ACh) and norepinephrine (NE) modulation corresponding to different physiological conditions (deep sleep, light sleep, relaxed wakefulness and attention). The model also shows that entrainment of thalamic oscillations is state-dependent.
Reference:
1 . Li G, Henriquez C, Fröhlich F (2017) Unified Thalamic Model Generates Multiple Distinct Oscillations with State-dependent Entrainment by Stimulation PLOS Computational Biology 13(10):e1005797
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism: Thalamus;
Cell Type(s): Thalamus geniculate nucleus/lateral principal neuron; Thalamus reticular nucleus cell; Thalamus lateral geniculate nucleus interneuron;
Channel(s): I Na,t; I K; I h; I L high threshold; I T low threshold; I_AHP; I CAN; I K,leak;
Gap Junctions: Gap junctions;
Receptor(s): AMPA; NMDA; GabaA;
Gene(s):
Transmitter(s): Acetylcholine; Norephinephrine;
Simulation Environment: C or C++ program;
Model Concept(s): Sleep; Activity Patterns; Gamma oscillations; Oscillations; Brain Rhythms;
Implementer(s): Li, Guoshi [guoshi_li at med.unc.edu];
Search NeuronDB for information about:  Thalamus geniculate nucleus/lateral principal neuron; Thalamus reticular nucleus cell; GabaA; AMPA; NMDA; I Na,t; I L high threshold; I T low threshold; I K; I K,leak; I h; I CAN; I_AHP; Acetylcholine; Norephinephrine;

#include "src/Ca_IN.h"
//#include "src/IT_TC.h"
//#include "src/Ih_TC.h"
//#include "src/INaK.h"
//#include "src/IA_TC.h"
//#include "src/INaP_TC.h"
//#include "src/IKs_TC.h"
//#include "src/Iahp_TC.h"
//#include "src/IT0_TC.h"
//#include "src/Ican_TC.h"
//#include "src/ICaL_TC.h"


class IN: public IT_TC, public Ih_TC, public INaK, public Ca_IN,
     public Iahp2, public Ican_TC {
  static double Cai0, V0;
public:
  double G_l, G_nal, G_kl, S_IN, E_l, I_Stim, i_Total;

  IN();
  void init(double *y);
  void calc(double x, double *y, double *f); 
    // Set stimulation
  void setStim(double);
};  

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