Paradoxical effect of fAHP amplitude on gain in dentate gyrus granule cells (Jaffe & Brenner 2017)

 Download zip file 
Help downloading and running models
Accession:235052
The afterhyperpolarization (AHP) is canonically viewed as a major factor underlying the refractory period, serving to limit neuronal firing rate. We recently reported (Wang et al, J. Neurophys. 116:456, 2016) that enhancing the amplitude of the fast AHP in a relatively slowly firing neuron (versus fast spiking neurons), augments neuronal excitability in dentate gyrus granule neurons expressing gain-of-function BK channels. Here we present a novel, quantitative hypothesis for how varying the amplitude of the fast AHP (fAHP) can, paradoxically, influence a subsequent spike tens of milliseconds later.
Reference:
1 . Jaffe DB, Brenner R (2018) A computational model for how the fast afterhyperpolarization paradoxically increases gain in regularly firing neurons. J Neurophysiol [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type:
Brain Region(s)/Organism: Dentate gyrus;
Cell Type(s): Dentate gyrus granule cell;
Channel(s): I K,Ca; I T low threshold; I Na,p;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Action Potentials;
Implementer(s): Jaffe, David B [david.jaffe at utsa.edu];
Search NeuronDB for information about:  Dentate gyrus granule cell; I Na,p; I T low threshold; I K,Ca;
/
Fig2
mods
README.html
601886b.nrn
Fig2.hoc
PlotFig2.py
screenshot2.png
                            
Loading data, please wait...