A detailed biophysical model for a neuron/astrocyte network is developed in order to explore mechanisms responsible for cortical spreading depolarizations. This includes a model for the Na+-glutamate transporter, which allows for a detailed description of reverse glutamate uptake. In particular, we consider the specific roles of elevated extracellular glutamate and K+ in the initiation, propagation and recurrence of spreading depolarizations.
Conte C, Lee R, Sarkar M, Terman D (2017) A mathematical model of recurrent spreading depolarizations. J Comput Neurosci [PubMed]