"During embryonic and adult neurogenesis, neural stem cells (NSCs)
generate the correct number and types of neurons in a temporospatial
fashion. Control of NSC activity and fate is crucial for brain
formation and homeostasis. Neurogenesis in the embryonic and adult
brain differ considerably, but Notch signaling and inhibitor of
DNA-binding (ID) factors are pivotal in both. Notch and ID factors
regulate NSC maintenance; however, it has been difficult to evaluate
how these pathways potentially interact. Here, we combined
mathematical modeling with analysis of single-cell transcriptomic data
to elucidate unforeseen interactions between the Notch and ID factor
pathways. ..."
Reference:
1 .
Boareto M, Iber D, Taylor V (2017) Differential interactions between Notch and ID factors control neurogenesis by modulating Hes factor autoregulation. Development 144:3465-3474 [PubMed]
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