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Perceptual judgments via sensory-motor interaction assisted by cortical GABA (Hoshino et al 2018)
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"Recurrent input to sensory cortex, via long-range reciprocal projections between motor and sensory cortices, is essential for accurate perceptual judgments. GABA levels in sensory cortices correlate with perceptual performance. We simulated a neuron-astrocyte network model to investigate how top-down, feedback signaling from a motor network (Nmot) to a sensory network (Nsen) affects perceptual judgments in association with ambient (extracellular) GABA levels. In the Nsen, astrocytic transporters modulated ambient GABA levels around pyramidal cells. A simple perceptual task was implemented: detection of a feature stimulus presented to the Nsen. ..."
Hoshino O, Zheng M, Watanabe K (2018) Perceptual judgments via sensory-motor interaction assisted by cortical GABA.
J Comput Neurosci
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Neocortex M1 interneuron basket PV GABA cell;
Neocortex U1 interneuron basket PV GABA cell;
Neocortex layer 4 pyramidal cell;
C or C++ program;
Hoshino, Osamu [osamu.hoshino.507 at vc.ibaraki.ac.jp];
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Neocortex M1 interneuron basket PV GABA cell
Neocortex U1 interneuron basket PV GABA cell
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