Perceptual judgments via sensory-motor interaction assisted by cortical GABA (Hoshino et al 2018)

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Accession:237727
"Recurrent input to sensory cortex, via long-range reciprocal projections between motor and sensory cortices, is essential for accurate perceptual judgments. GABA levels in sensory cortices correlate with perceptual performance. We simulated a neuron-astrocyte network model to investigate how top-down, feedback signaling from a motor network (Nmot) to a sensory network (Nsen) affects perceptual judgments in association with ambient (extracellular) GABA levels. In the Nsen, astrocytic transporters modulated ambient GABA levels around pyramidal cells. A simple perceptual task was implemented: detection of a feature stimulus presented to the Nsen. ..."
Reference:
1 . Hoshino O, Zheng M, Watanabe K (2018) Perceptual judgments via sensory-motor interaction assisted by cortical GABA. J Comput Neurosci 44:233-251 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network; Extracellular;
Brain Region(s)/Organism:
Cell Type(s): Neocortex M1 interneuron basket PV GABA cell; Neocortex U1 interneuron basket PV GABA cell; Astrocyte; Neocortex layer 4 pyramidal cell;
Channel(s):
Gap Junctions:
Receptor(s): AMPA; Gaba;
Gene(s):
Transmitter(s): Gaba;
Simulation Environment: C or C++ program;
Model Concept(s):
Implementer(s): Hoshino, Osamu [osamu.hoshino.507 at vc.ibaraki.ac.jp];
Search NeuronDB for information about:  Neocortex M1 interneuron basket PV GABA cell; Neocortex U1 interneuron basket PV GABA cell; AMPA; Gaba; Gaba;
 
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HoshinoEtAl2018
                            
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