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Locational influence of dendritic PIC on input-output properties of spinal motoneurons (Kim 2017)
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How does the dendritic location of calcium persistent inward current (Ca-PIC) influence dendritic excitability and firing behavior across the spinal motoneuron pool? This issue was investigated developing a model motoneuron pool where model parameters were analytically determined to reflect key motoneuron type-specific properties experimentally identified. The simulation results point out the negative relationship between the distance of Ca-PIC source from the soma and cell recruitment threshold as a basis underlying the systematic variation in input-output properties of motoneurons over the motoneuron pool.
Kim H (2017) Impact of the localization of dendritic calcium persistent inward current on the input-output properties of spinal motoneuron pool: a computational study.
J Appl Physiol (1985)
Kim H, Jones KE, Heckman CJ (2014) Asymmetry in signal propagation between the soma and dendrites plays a key role in determining dendritic excitability in motoneurons.
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Neuron or other electrically excitable cell;
Spinal cord lumbar motor neuron alpha ACh cell;
Kim, Hojeong [hojeong.kim03 at gmail.com];
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Spinal cord lumbar motor neuron alpha ACh cell
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