" ...Currently, no mechanistic framework describes how network dynamics, glutamate, and serotonin interact to explain MDD symptoms and treatments. Here, we built a biophysical computational model of 2 areas (vACC and dlPFC) that can switch between emotional and cognitive processing. (Major Depression Disease) MDD networks were simulated by slowing glutamate decay in vACC and demonstrated sustained vACC activation. ..."
Ramirez-Mahaluf JP, Roxin A, Mayberg HS, Compte A (2017) A Computational Model of Major Depression: the Role of Glutamate Dysfunction on Cingulo-Frontal Network Dynamics. Cereb Cortex 27:660-679 [PubMed]