"Gene regulatory networks (GRNs) describe interactions between gene
products and transcription factors that control gene expression. In
combination with reaction–diffusion models, GRNs have enhanced
comprehension of biological pattern formation. However, although it is
well known that biological systems exploit an interplay of genetic and
physical mechanisms, instructive factors such as transmembrane
potential (Vmem) have not been integrated into full GRN models. Here
we extend regulatory networks to include bioelectric signalling,
developing a novel synthesis: the bioelectricity-integrated gene and
reaction (BIGR) network.
..."
Reference:
1 .
Pietak A, Levin M (2017) Bioelectric gene and reaction networks: computational modelling of genetic, biochemical and bioelectrical dynamics in pattern regulation. J R Soc Interface [PubMed]
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