"Presurgical planning for brain tumor resection aims at delineating
eloquent tissue in the vicinity of the lesion to spare during
surgery.
... we simulated large-scale brain dynamics in 25
human brain tumor patients and 11 human control participants using The
Virtual Brain, an open-source neuroinformatics platform. Local and
global model parameters of the Reduced Wong–Wang model were
individually optimized and compared between brain tumor patients and
control subjects. In addition, the relationship between model
parameters and structural network topology and cognitive performance
was assessed. Results showed (1) significantly improved prediction
accuracy of individual functional connectivity when using individually
optimized model parameters; (2) local model parameters that can
differentiate between regions directly affected by a tumor, regions
distant from a tumor, and regions in a healthy brain; and (3)
interesting associations between individually optimized model
parameters and structural network topology and cognitive performance."
Reference:
1 .
Aerts H, Schirner M, Jeurissen B, Van Roost D, Achten E, Ritter P, Marinazzo D (2018) Modeling Brain Dynamics in Brain Tumor Patients Using the Virtual Brain. eNeuro [PubMed]
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