Coincident signals in Olfactory Bulb Granule Cell spines (Aghvami et al 2019)

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Accession:244687
"In the mammalian olfactory bulb, the inhibitory axonless granule cells (GCs) feature reciprocal synapses that interconnect them with the principal neurons of the bulb, mitral, and tufted cells. These synapses are located within large excitable spines that can generate local action potentials (APs) upon synaptic input (“spine spike”). Moreover, GCs can fire global APs that propagate throughout the dendrite. Strikingly, local postsynaptic Ca2+ entry summates mostly linearly with Ca2+ entry due to coincident global APs generated by glomerular stimulation, although some underlying conductances should be inactivated. We investigated this phenomenon by constructing a compartmental GC model to simulate the pairing of local and global signals as a function of their temporal separation ?t. These simulations yield strongly sublinear summation of spine Ca2+ entry for the case of perfect coincidence ?t = 0 ms. ..."
Reference:
1 . Aghvami SS, Müller M, Araabi BN, Egger V (2019) Coincidence Detection within the Excitable Rat Olfactory Bulb Granule Cell Spines. J Neurosci 39:584-595 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Dendrite; Channel/Receptor; Synapse;
Brain Region(s)/Organism: Olfactory bulb;
Cell Type(s): Olfactory bulb main interneuron granule MC GABA cell; Olfactory bulb main interneuron granule TC GABA cell;
Channel(s): Ca pump; I Calcium; I K; I Sodium;
Gap Junctions:
Receptor(s): NMDA; AMPA;
Gene(s):
Transmitter(s): Glutamate;
Simulation Environment: NEURON; Python;
Model Concept(s): Active Dendrites; Calcium dynamics; Coincidence Detection;
Implementer(s): Aghvami, S. Sara [ssa.aghvami at gmail.com];
Search NeuronDB for information about:  Olfactory bulb main interneuron granule MC GABA cell; Olfactory bulb main interneuron granule TC GABA cell; AMPA; NMDA; I K; I Sodium; I Calcium; Ca pump; Glutamate;
There are 6 tests for checking the robustness of the model against main parameters random changes (50%~200%). 
As the codes for all these 6 parameters are quite similar, and avoiding redundancy, we put just one here
for testing robustness against changes in  T-type Ca2+ channels conductivity.
For the other five tests, same strategy is to be used.

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