Ca2+ requirements for Long-Term Depression in Purkinje Cells (Criseida Zamora et al 2018)

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Accession:245412
An updated stochastic model of cerebellar Long-Term Depression (LTD) to study the requirements of calcium to induce LTD. Calcium signal is generated as a train of calcium pulses and this can be modulated by its amplitude, frequency, width and number of pulses. CaMKII activation and its regulatory pathway are added to an earlier published model to study the sensitivity to calcium frequency. The model is useful to investigate systematically the dependence of LTD induction on calcium stimuli parameters.
Reference:
1 . Zamora Chimal CG, De Schutter E (2018) Ca2+ Requirements for Long-Term Depression Are Frequency Sensitive in Purkinje Cells. Front Mol Neurosci 11:438 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Molecular Network; Synapse;
Brain Region(s)/Organism: Cerebellum;
Cell Type(s): Cerebellum Purkinje GABA cell;
Channel(s):
Gap Junctions:
Receptor(s): AMPA;
Gene(s):
Transmitter(s):
Simulation Environment: STEPS;
Model Concept(s): Synaptic Plasticity; Long-term Synaptic Plasticity; Signaling pathways; Stochastic simulation;
Implementer(s): Zamora, Criseida [criseida.chimal at oist.jp];
Search NeuronDB for information about:  Cerebellum Purkinje GABA cell; AMPA;
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CaMKII_LTD_model
readme.fld
readme.html
camk_ltd.py
                            
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