Neurogenesis in the olfactory bulb controlled by top-down input (Adams et al 2018)

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Accession:247188
This code implements a model for adult neurogenesis of granule cells in the olfactory system. The granule cells receive sensory input via the mitral cells and top-down input from a cortical area. That cortical area also receives olfactory input from the mitral cells as well as contextual input. This plasticity leads to a network structure consisting of bidirectional connections between bulbar and cortical odor representations. The top-down input enhances stimulus discrimination based on contextual input.
Reference:
1 . Adams W, Graham JN, Han X, Riecke H (2019) Top-down inputs drive neuronal network rewiring and context-enhanced sensory processing in olfaction. PLoS Comput Biol 15:e1006611 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism: Olfactory bulb; Olfactory cortex;
Cell Type(s): Abstract integrate-and-fire neuron;
Channel(s):
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: MATLAB;
Model Concept(s): Activity Patterns; Neurogenesis; Memory; Olfaction; Pattern Separation; Sensory processing; Top-down input;
Implementer(s): Riecke, Hermann [h-riecke at northwestern.edu];
 
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