Two forms of synaptic depression by neuromodulation of presynaptic Ca2+ channels (Burke et al 2018)


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Accession:266534
"... To determine whether the different biophysical mechanisms of CaV modulation predicted by OFA (Optical Fluctuation Analysis) are sufficient to explain the differing effects of D1Rs and GABA B Rs on STP, we developed a reduced synaptic model..."
Reference:
1 . Burke KJ, Keeshen CM, Bender KJ (2018) Two Forms of Synaptic Depression Produced by Differential Neuromodulation of Presynaptic Calcium Channels. Neuron 99:969-984.e7 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Synapse; Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Prefrontal cortex (PFC);
Cell Type(s):
Channel(s): I Calcium;
Gap Junctions:
Receptor(s): Dopaminergic Receptor;
Gene(s):
Transmitter(s):
Simulation Environment: Python (web link to model);
Model Concept(s): Facilitation; Short-term Synaptic Plasticity; Synaptic Plasticity; Calcium dynamics;
Implementer(s):
Search NeuronDB for information about:  Dopaminergic Receptor; I Calcium;
(located via links below)
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