Cardiac models of circadian rhythms in early afterdepolarizations & arrhythmias (Diekman & Wei 2021)

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Accession:266974
We fit a simplified Luo-Rudy model to voltage-clamp data showing a circadian rhythm in L-type calcium conductance. Simulations of the model (single-cell and 2-D spatial versions) suggest that circadian rhythms in early afterdepolarizations may contribute to daily rhythms in cardiac arrhythmias and sudden cardiac death.
Reference:
1 . Diekman CO, Wei N (2021) Circadian Rhythms of Early Afterdepolarizations and Ventricular Arrhythmias in a Cardiomyocyte Model. Biophys J 120:319-333 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Cardiac ventricular cell;
Channel(s): I Calcium; I K;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: MATLAB;
Model Concept(s): Circadian Rhythms; Action Potentials; Cardiac pacemaking; Bifurcation;
Implementer(s): Diekman, Casey O. [casey.o.diekman at njit.edu];
Search NeuronDB for information about:  I K; I Calcium;
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