Ventromedial Thalamocortical Neuron (Bichler et al 2021)

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Accession:266989
"Biophysical computer modeling of a thalamic neuron demonstrated that an increase in rebound spiking can also be accounted for by a decrease in the M-type potassium current. Modeling also showed that an increase in sag with hyperpolarizing steps found after 6-OHDA treatment could in part but not fully be accounted for by the decrease in M-type current. These findings support the hypothesis that homeostatic changes in BGMT neural properties following 6-OHDA treatment likely influence the signal processing taking place in the BG thalamocortical network in Parkinson's disease."
Reference:
1 . Bichler EK, Cavarretta F, Jaeger D (2021) Changes in Excitability Properties of Ventromedial Motor Thalamic Neurons in 6-OHDA Lesioned Mice. eNeuro [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Thalamus;
Cell Type(s):
Channel(s): I A; I h; I L high threshold; I T low threshold; I K,Ca; I Sodium; I Potassium; I Na,p; I K;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON; Python;
Model Concept(s): Pathophysiology;
Implementer(s):
Search NeuronDB for information about:  I Na,p; I L high threshold; I T low threshold; I A; I K; I h; I K,Ca; I Sodium; I Potassium;
 This model entry contains the NEURON code for:

Bichler EK, Cavarretta F, Jaeger D (2021) Changes in Excitability Properties of Ventromedial Motor Thalamic Neurons in 6-OHDA Lesioned Mice. eNeuro 8(1): ENEURO.0436-20.2021. doi: 10.1523/ENEURO.0436-20.2021.

Requirements:
NEURON v. 7.7+
Python v. 3.7+ with SciPy, NumPy, PyNWB, and MatPlotLib


To run:

1. Compile the mod files by typing:

nrnivmodl

2. Generate the simulated data (ie, run the simulations):

nrniv -python sag_sim.py 
nrniv -python rebound_sim.py 
nrniv -python fi_curve_sim.py

Alternatively, you may execute the command replacing "nrniv -python" with "python" or "python3".

3. Visualize the data (ie, reproduce Figure 6 in Bichler et al, 2021):
python fig_vis.py

Do not hesitate to contact me via email for additional information:
francesco.cavarretta@emory.edu or francescocavarretta@hotmail.it



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