Information trans. through Entopeduncular nucleus modified by synaptic plasticity (Gorodetsky et al)

 Download zip file 
Help downloading and running models
Accession:267049
Multicompartmental model of EP neuron was created using automatic parameter optimization. We included both short term plasticity and long term plasticity. We simulated the response to inputs from globus pallidus, striatum and subthalamic nucleus. We show that dopamine long term plasticity enhances information transmission from striatum and reduces GPe and STN information transmission.
Reference:
1 . Gorodetski L, Loewenstern Y, Faynveitz A, Bar-Gad I, Blackwell KT, Korngreen A (2021) Endocannabinoids and Dopamine Balance Basal Ganglia Output. Front Cell Neurosci 15:639082 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Basal ganglia;
Cell Type(s): Globus pallidus neuron;
Channel(s): I Sodium; I Potassium; I Calcium; I CNG; IK Bkca; IK Skca; I_KD;
Gap Junctions:
Receptor(s): GabaA; Glutamate;
Gene(s):
Transmitter(s):
Simulation Environment: MOOSE/PyMOOSE;
Model Concept(s):
Implementer(s): Blackwell, Avrama [avrama at gmu.edu];
Search NeuronDB for information about:  GabaA; Glutamate; I CNG; I Sodium; I Calcium; I Potassium; I_KD; IK Bkca; IK Skca;
 
/
moose_nerp
                            
File not selected

<- Select file from this column.
Loading data, please wait...