Layer-specific pyramidal cell props underlie diverse ACC motor + limbic networks (Medalla et al '21)

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Accession:267128
"A MATLAB-based model of pyramidal-interneuron network was extended from [modeldb.yale.edu/138421]... to simulate how intrinsic biophysical properties and inhibition can affect network synchrony and oscillatory frequencies in ACC L3 and L5... Four different networks were simulated depending on a subset of empirically derived biophysical, morphological and connectional properties of lamina- and target- specific ACC pyramidal neurons... our model is constrained by in vitro whole cell patch clamp recording data from the soma."
Reference:
1 . Medalla M, Chang W, IbaƱez S, Guillamon-Vivancos T, Nittmann M, Kapitonava A, Busch SE, Moore TL, Rosene DL, Luebke JI (2021) Layer-specific pyramidal neuron properties underlie diverse anterior cingulate cortical motor and limbic networks Cerebral Cortex
Model Information (Click on a link to find other models with that property)
Model Type:
Brain Region(s)/Organism:
Cell Type(s): Hodgkin-Huxley neuron; Abstract Wang-Buzsaki neuron;
Channel(s):
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: MATLAB;
Model Concept(s): Oscillations; Action Potentials; Spike Frequency Adaptation;
Implementer(s):
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Codes_and_ReadMe
fast&slow_Adaptation
no_Adaptation
ReadMe.txt
                            
For both codes, including and not including adaptation, comment or uncomment corresponding lines in files "initialize" and "params". 

Files:

gamma_simulator: main file.

rastergram3: makes the raster plots.

initialize: contains initial conditions for the 4 networks (L3 to PMd, L5 to PMd, L3 to AMY, L5 to AMY).
	No adaptation:
	Comment/uncomment lines from: 4-6, 9-11, 14-16, 19-21, correspondingly for each network. 
	Adaptation:
	Comment/uncomment lines from: 4-7, 10-13, 16-19, 22-25, correspondingly for each network. 

params: contains the parameters of the system for the 4 networks.
	No adaptation:
	Comment/uncomment lines from: 22-25, 36-46, 74-88, correspondingly for each network.
	Modify line 107 to change the deterministic drive.
	Uncomment line 110 to have only a deterministic drive.
	Comment line 110 and uncomment lines 111 or 112 to add a stochastic drive.

	Adaptation:
	Comment/uncomment lines from: 44-52, 63-73, 101-115, correspondingly for each network.
	Modify line 134 to change the deterministic drive.
	Uncomment line 139 to have only a deterministic drive.
	Comment line 139 and uncomment lines 140 or 141 to add a stochastic drive.
	Change the percentage in line 6 and g_sa in line 25 accordingly for each network.


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