Spinal motoneuron recruitment regulated by ionic channels during fictive locomotion (Zhang & Dai 20)

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Accession:267176
"... we investigated the channel mechanism regulating the motoneuron recruitment. Three types of motoneuron pools including slow (S), fatigue-resistant (FR) and fast-fatigable (FF) motoneurons were constructed based on the membrane proprieties of cat lumbar motoneurons. The transient sodium (NaT), persistent sodium (NaP), delayed-rectifier potassium [K(DR)], Ca2+-dependent K+ [K(AHP)] and L-type calcium (CaL) channels were included in the models..."
Reference:
1 . Zhang Q, Dai Y (2020) A modeling study of spinal motoneuron recruitment regulated by ionic channels during fictive locomotion J Comp Neuro 48:409-428 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Spinal cord motor neuron fast fatiguing; Spinal cord motor neuron fatigue resistant; Spinal cord motor neuron slow twitch;
Channel(s): I Na,t; I Na,p; I K; I_AHP; I L high threshold;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s):
Implementer(s): Zhang, Qiang;
Search NeuronDB for information about:  I Na,p; I Na,t; I L high threshold; I K; I_AHP; 
Readme for the models associated with the paper:

Qiang Zhang, Yue Dai. A modeling study of spinal motoneuron recruitment regulated
by ionic channels during fictive locomotion. Journal of Computational Neuroscience 2020.


How to run model:

Download and extract archive and compile the mod files with
mknrndll (mswin). Then double clicking main.hoc (mswin)

Once the model has started press Init&Run to generate fig 2c (brown curve).

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Model written by Qiang Zhang, 2020.   
Email:2487657812@qq.com

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