Computational model of cerebellar tDCS (Zhang et al., 2021)

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Accession:267189
This archive contains models used in (Zhang et al. 2021) and simulates Purkinje cell, granule cell, and deep cerebellar neuron activities under cerebellar tDCS (transcranial direct current stimulation).
Reference:
1 . Zhang X, Hancock R, Santaniello S (2021) Transcranial Direct Current Stimulation of Cerebellum Alters Spiking Precision in Cerebellar Cortex: A Modeling Study of Cellular Responses. PLoS Comp Biol 17(12):e1009609 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Cerebellum;
Cell Type(s): Cerebellum Purkinje GABA cell; Cerebellum interneuron granule GLU cell; Cerebellum deep nucleus neuron;
Channel(s):
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s):
Implementer(s):
Search NeuronDB for information about:  Cerebellum Purkinje GABA cell; Cerebellum interneuron granule GLU cell;
// Simulate Purkinje cell (Masoli et al.,2015) activity during calcium bursting
// with voltage shifts applied to all dendritic compartments
// (c) Xu (Shawn) Zhang, UConn
// xu.3.zhang@uconn.edu

load_file("nrngui.hoc")


load_file("Purkinje_calcium_dend_vshift.hoc")

cvode.active(0)

// axonAIS.pcabar_Cav3_1 = 0
// axonAIS.pcabar_Cav2_1 = 0
// axonAIS.gbar_Nav1_6 = 0

dt = 0.025
celsius = 37
tstop = 2400
v_init = -50

objref f_trialname
f_trialname = new File()
f_trialname.ropen("trialname_calcium_dend_vshift.txt")
strdef f_soma
f_trialname.scanstr(f_soma)
f_trialname.close()

// Inducing calcium spikes
stim0del = 200
stim0dur = 200000
stim0amp = 2

objref stim
soma stim = new IClamp(0.5)
stim.del = stim0del
stim.dur = stim0dur
stim.amp = stim0amp

// Record soma
objref rec_v_soma
rec_v_soma = new Vector()
rec_v_soma.record(&soma.v(0.5))

access soma
// load_file("vm.ses")

finitialize(v_init)
run()

// Save soma
objref sav_v_soma
sav_v_soma = new File()
sav_v_soma.wopen(f_soma)
rec_v_soma.printf(sav_v_soma)
sav_v_soma.close()

quit()

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