Low Threshold Calcium Currents in TC cells (Destexhe et al 1998)

 Download zip file   Auto-launch 
Help downloading and running models
Accession:279
In Destexhe, Neubig, Ulrich, and Huguenard (1998) experiments and models examine low threshold calcium current's (IT, or T-current) distribution in thalamocortical (TC) cells. Multicompartmental modeling supports the hypothesis that IT currents have a density at least several fold higher in the dendrites than the soma. The IT current contributes significantly to rebound bursts and is thought to have important network behavior consequences. See the paper for details. See also http://cns.iaf.cnrs-gif.fr Correspondance may be addressed to Alain Destexhe: Destexhe@iaf.cnrs-gif.fr
Reference:
1 . Destexhe A, Neubig M, Ulrich D, Huguenard J (1998) Dendritic low-threshold calcium currents in thalamic relay cells. J Neurosci 18:3574-88 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Thalamus geniculate nucleus/lateral principal neuron;
Channel(s): I Na,t; I T low threshold; I K;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Dendritic Action Potentials; Bursting; Ion Channel Kinetics; Parameter Fitting; Simplified Models; Influence of Dendritic Geometry; Detailed Neuronal Models; Calcium dynamics; Rebound firing;
Implementer(s): Destexhe, Alain [Destexhe at iaf.cnrs-gif.fr];
Search NeuronDB for information about:  Thalamus geniculate nucleus/lateral principal neuron; I Na,t; I T low threshold; I K;
/
dendtc
cells
README
cadecay.mod *
hh2.mod *
ITGHK.mod *
VClamp.mod *
El.oc *
loc200.oc
loc3.oc *
locD.oc
mosinit.hoc *
rundemo.hoc
tc1_cc.oc
tc200_cc.oc
tc200_vc.oc
tc3_cc.oc
tcD_vc.oc
                            
 NEURON TUTORIAL FOR IMPLEMENTING SIMULATIONS OF THALAMIC RELAY NEURONS

                          Alain Destexhe
		Laboratory for Computational Neuroscience
	Unité de Neurosciences Intégratives et Computationnelles (UNIC)
	Centre National de la Recherche Scientifique (CNRS)
			91198 Gif-sur-Yvette, France 

	    Formerly from (when this work was created):
            Department of Physiology, Laval University,
                      Quebec G1K 7P4, Canada

                       Destexhe@iaf.cnrs-gif.fr
                     http://cns.iaf.cnrs-gif.fr/Main.html


This package is running with the NEURON simulation program written by Michael
Hines and available on internet at:
  http://www.neuron.yale.edu/neuron/
  http://neuron.duke.edu/

The package contains mechanisms (.mod files) and programs (.oc files) needed
to simulate different models of thalamocortical (TC) relay neurons, relative
to the paper:

   Destexhe A, Neubig M, Ulrich D and Huguenard JR.  
   Dendritic low-threshold calcium currents in thalamic relay cells.  
   Journal of Neuroscience 18: 3574-3588, 1998.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9570789&dopt=Abstract

A postscript version of this paper, including figures, is available on
internet at 
  http://cns.iaf.cnrs-gif.fr/Main.html
  
  PROGRAMS
  ========

tc1_cc.o c  : current clamp in 1-compartment TC cell
tc3_cc.oc   : current clamp in 3-compartment TC cell
tc200_cc.oc : current clamp in 200-compartment TC cell (intact cell)
tc200_vc.oc : voltage clamp in 200-compartment TC cell (intact cell)
tcD_cc.oc   : current clamp in 8-compartment TC cell (dissociated cell)
tcD_vc.oc   : voltage clamp in 8-compartment TC cell (dissociated cell)


  MECHANISMS
  ==========

 hh2.mod		: fast sodium spikes (Na and K currents)
 ITGHK.mod		: T-type calcium current of TC cells
 cadecay.mod		: intracellular calcium dynamics
 VClamp.mod		: mechanism for single-electrode voltage-clamp


  HOW TO RUN
  ==========

Use autolaunch on modeldb or:

unix platform:

  To compile the demo, NEURON and INTERVIEWS must be installed and working on
  the machine you are using.  Just type "nrnivmodl" to compile the mechanisms
  given in the mod files.

  Then, execute the main demo program by typing:

  nrngui mosinit.hoc

mswin platform:

  Compile the mechanism (mod) files by using mknrndll.  Then start the simulation
  by clicking on mosinit.hoc in windows explorer.

back to any platform:

Once the menu and graphics interface has appeared, click on a simulation from
the Simulations of TC cells window.  Then click on "Init and Run"
button to start the simulation on the RunControl window.  If you do not see a RunControl
window you can bring it to the front by selecting it under Tools from the NEURON main menu.

For more information about how to get NEURON and how to install it, please
refer to the following sites:
  http://www.neuron.yale.edu/neuron/
  http://neuron.duke.edu/

For further information, please contact:

Alain Destexhe
Laboratory for Computational Neuroscience
Unité de Neurosciences Intégratives et Computationnelles (UNIC)
Centre National de la Recherche Scientifique (CNRS)
91198 Gif-sur-Yvette, France 

Destexhe@iaf.cnrs-gif.fr
http://cns.iaf.cnrs-gif.fr/Main.html

Further updated 7/10/05 for button restart fix
.model version 10/28/02 updated to neuron 5.2.


Loading data, please wait...