Action potential initiation in the olfactory mitral cell (Shen et al 1999)

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Accession:3342
Mitral cell model with standard parameters for the paper: Shen, G.Y., Chen, W. R., Midtgaard, J., Shepherd, G.M., and Hines, M.L. (1999) Computational Analysis of Action Potential Initiation in Mitral Cell Soma and Dendrites Based on Dual Patch Recordings. Journal of Neurophysiology 82:3006. Contact Michael.Hines@yale.edu if you have any questions about the implementation of the model.
Reference:
1 . Shen GY, Chen WR, Midtgaard J, Shepherd GM, Hines ML (1999) Computational analysis of action potential initiation in mitral cell soma and dendrites based on dual patch recordings. J Neurophysiol 82:3006-20 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Olfactory bulb main mitral cell; Myelinated neuron;
Channel(s): I Na,t; I K; I Sodium; I Potassium;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Action Potential Initiation; Dendritic Action Potentials; Parameter Fitting; Active Dendrites;
Implementer(s): Hines, Michael [Michael.Hines at Yale.edu];
Search NeuronDB for information about:  Olfactory bulb main mitral cell; I Na,t; I K; I Sodium; I Potassium;
Mitral cell model with standard parameters for the paper:

Shen, G.Y., Chen, W. R., Midtgaard, J., Shepherd, G.M., and Hines, M.L.
(1999)
Computational Analysis of Action Potential Initiation in Mitral
Cell Soma and Dendrites Based on Dual Patch Recordings.
Journal of Neurophysiology  82: 3006

Questions about how to use this simulation should be
directed to
	michael.hines@yale.edu

Running the model (execution of the mosinit.hoc file) will display
the data and simulation results as in  Fig 3 and 5.

The cell2 subdirectory contains cell data and simulation which shows
only a limited decrease in the action potential interval.
Running the model (cd cell2 and execute the mosinit.hoc file)
will display the data and simulation within a Multiple Run Fitter.


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