Retinal Ganglion Cell: I-K (Skaliora et al 1995)

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Accession:3491
NEURON mod files for the K-DR current from the paper: Skaliora I, Robinson DW, Scobey RP, Chalupa LM. Properties of K+ conductances in cat retinal ganglion cells during the period of activity-mediated refinements in retinofugal pathways. Eur J Neurosci 1995 7(7):1558-1568. See the readme.txt file below for more information.
Reference:
1 . Skaliora I, Robinson DW, Scobey RP, Chalupa LM (1995) Properties of K+ conductances in cat retinal ganglion cells during the period of activity-mediated refinements in retinofugal pathways. Eur J Neurosci 7:1558-68 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Channel/Receptor;
Brain Region(s)/Organism:
Cell Type(s): Retina ganglion cell;
Channel(s): I K; I Potassium;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Ion Channel Kinetics;
Implementer(s): Migliore, Michele [Michele.Migliore at Yale.edu];
Search NeuronDB for information about:  Retina ganglion cell; I K; I Potassium;
NEURON mod files for the K-DR current from the paper:
Skaliora, et al., Eur.J.Neurosci. 7:1558-1568 (1995).

Running the kinetics.hoc simulation file will show 
the activation and inactivation steady-states, the time constants, 
and a family of curves generated modeling the same protocols 
used for Figs.4B of the paper.

Parameters values are from postnatal cells, and markers show
the experimental values reported in the paper.
Note that the time constant of inactivation is faster in postnatal cells,
and m is plotted rather than m^3 for activation. 
The peak conductance has been adjusted to give approximately the
same peak currents shown in the experiments.
 
Under unix systems:
to compile the mod files use the command 
nrnivmodl 
and run the simulation hoc file with the command 
nrngui kinetics.hoc

Under Windows using NEURON 5.1:
to compile the mod files use the "mknrndll" command.
A double click on the simulation file
kinetics.hoc 
will open the simulation window.

Questions on the model parameters should be directed to the 
authors.

Questions on how to use this model with NEURON
should be directed to michele@pa.ibf.cnr.it

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