Xenopus Myelinated Neuron (Frankenhaeuser, Huxley 1964)

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Accession:3507
Frankenhaeuser, B. and Huxley, A. F. (1964), The action potential in the myelinated nerve fiber of Xenopus Laevis as computed on the basis of voltage clamp data. J. Physiol. 171: 302-315. See README file for more information.
Reference:
1 . FRANKENHAEUSER B, HUXLEY AF (1964) THE ACTION POTENTIAL IN THE MYELINATED NERVE FIBER OF XENOPUS LAEVIS AS COMPUTED ON THE BASIS OF VOLTAGE CLAMP DATA. J Physiol 171:302-15 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Axon;
Brain Region(s)/Organism:
Cell Type(s):
Channel(s): I Na,t; I Potassium;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Axonal Action Potentials;
Implementer(s): Hines, Michael [Michael.Hines at Yale.edu];
Search NeuronDB for information about:  I Na,t; I Potassium;
/
fh
README
fh.mod *
fh.hoc
mosinit.hoc
                            
/* Frankenhaeuser-Huxley action potential, Fig 1 to Fig 6 */
load_file("nrngui.hoc")

// Physical properties
create node
access node
{ nseg=1  L=2  diam=8  cm=2
  insert fh
  nai=13.74  nao=114.5  ki=120 ko=2.5
}
areafac = PI*L*diam/100		/* mamps/cm^2 to namps (units of 1e-6 cm^2) */
{celsius=20}

// experimental tools
objref stim
stim = new IClamp(.5)
stim.dur=.12
stim.amp = 1*areafac

// run parameters
cvode_active(1)

// graphical interface appearance
objref g
g = new Graph(0)
g.view(0, 0, 2, 100, 120, 110, 300, 200)
addplot(g,1)

// simulation control
v_init = -70

proc fig1() {
	g.erase_all()
	g.size(0,2.2,-5,120)
	g.addexpr("v+70",2,1)
	tstop = 2
	run()
}

proc fig3() {
	g.erase_all()
	g.size(0,3,0,1)
	g.addexpr("m_fh",2,1)
	g.addexpr("h_fh",3,1)
	g.addexpr("n_fh",4,1)
	g.addexpr("p_fh",5,1)
	tstop=3
	run()
}

proc fig6() {
	g.erase_all
	g.size(0,2,-10,5)
	g.addexpr("ina",2,1)
	g.addexpr("ik",3,1)
	g.addexpr("ip_fh",4,1)
	g.addexpr("il_fh",5,1)
	tstop = 2
	run()
}

proc menu() {
	xpanel("Frankenhaeuser-Huxley action potential")
	xbutton("fig 1", "fig1()")
	xbutton("fig 3", "fig3()")
	xbutton("fig 6", "fig6()")
	xpanel(0,100)
}
// run simulation
menu()


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