Regulation of a slow STG rhythm (Nadim et al 1998)

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Frequency regulation of a slow rhythm by a fast periodic input. Nadim, F., Manor, Y., Nusbaum, M. P., Marder, E. (1998) J. Neurosci. 18: 5053-5067
1 . Nadim F, Manor Y, Nusbaum MP, Marder E (1998) Frequency regulation of a slow rhythm by a fast periodic input. J Neurosci 18:5053-67 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism: Stomatogastric ganglion;
Cell Type(s): Stomatogastric Ganglion (STG) Modulatory commissural neuron 1 (MCN1); Stomatogastric Ganglion (STG) interneuron 1 (Int1); Stomatogastric Ganglion (STG) Lateral Gastric (LG) cell;
Channel(s): I Na,t; I K;
Gap Junctions: Gap junctions;
Simulation Environment: NEURON;
Model Concept(s): Temporal Pattern Generation; Invertebrate;
Implementer(s): Nadim, Farzan [Farzan at];
Search NeuronDB for information about:  I Na,t; I K;
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Nadim F, Manor Y, Nusbaum MP, Marder E.
Frequency regulation of a slow rhythm by a fast periodic input.
J Neurosci 1998 Jul 1;18(13):5053-67

   Many nervous systems contain rhythmically active subnetworks that
interact despite oscillating at widely different frequencies.  The
stomatogastric nervous system of the crab Cancer borealis produces a
rapid pyloric rhythm and a considerably slower gastric mill rhythm.  We
construct and analyze a conductance-based compartmental model to explore
the activation of the gastric mill rhythm by the modulatory commissural
neuron 1 (MCN1)
   This model demonstrates that the period of the MCN1-activated gastric
mill rhythm, which was thought to be determined entirely by the
interaction of neurons in the gastric mill network, can be strongly
influenced by inhibitory synaptic input from the pacemaker neuron of the
fast pyloric rhythm, the anterior burster (AB) neuron.  Surprisingly,
the change of the gastric mill period produced by the pyloric input to
the gastric mill system can be many times larger than the period of the
pyloric rhythm itself.  This model illustrates several mechanisms by
which a fast oscillatory neuron may control the frequency of a much
slower oscillatory network.  These findings suggest that it is possible
to modify the slow rhythm either by direct modulation or indirectly by
modulating the faster rhythm. 

PMID: 9634571 [PubMed - indexed for MEDLINE] 

The full text of this article can be seen at

Note: The NEURON version 5.1 variable step absolute tolerance has been set 
produce a simulation similar to that of the fixed step crank-nicholson
method with dt=.05(ms). For NEURON version 4.3.1, the tolerance can
be set to 0.01 .

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