NEURON mod files for the Ca-T current from the paper:
Williams SR, Stuart GJ, Action potential backpropagation and
somato-dendritic distribution of ion channels in thalamocortical neurons.
J Neurosci. 2000 20:1307-17.
Running the kinetics.hoc simulation file will show
the activation and inactivation steady-states, the time constants,
and a family of curves generated modeling the protocols
indicated in the paper.
Parameters for the Boltzmann equation fitting
the activation (m^3) and inactivation (h) steady states
were those reported in the paper (p.1313).
prepulses, and test pulses, were reported in the paper as
relative to a resting membrane potential, and the model
uses the Nerst's equation to calculate the Calcium reversal potential.
Thus, the model's parameter vrest_cat (the resting potential)
and the initial values of Calcium concentrations (cao and cai)
need to be defined in hoc.
Time constants were not reported in the paper. In the model,
they have been adjusted to give a reasonable approximation of the
voltage-clamp current traces in Figs.8A-B.
Under unix systems:
to compile the mod files use the command
and run the simulation hoc file with the command
Under Windows using NEURON 5.1:
to compile the mod files use the "mknrndll" command.
A double click on the simulation file
will open the simulation window.
Questions on how to use this model should be directed to