Olfactory Periglomerular Cells: I-h kinetics (Cadetti, Belluzzi 2001)

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Accession:3665
NEURON mod files for the Ih current from the paper: Cadetti L, Belluzzi O. Hyperpolarisation-activated current in glomerular cells of the rat olfactory bulb. Neuroreport 12:3117-20 (2001).
Reference:
1 . Cadetti L, Belluzzi O (2001) Hyperpolarisation-activated current in glomerular cells of the rat olfactory bulb. Neuroreport 12:3117-20 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Channel/Receptor;
Brain Region(s)/Organism:
Cell Type(s):
Channel(s): I h;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Ion Channel Kinetics;
Implementer(s): Migliore, Michele [Michele.Migliore at Yale.edu];
Search NeuronDB for information about:  I h;
NEURON mod files for the Ih current from the paper:
Cadetti L, Belluzzi O.
Hyperpolarisation-activated current in glomerular cells 
of the rat olfactory bulb.
Neuroreport 12:3117-20 (2001).

Running the kinetics.hoc simulation file will show 
the activation steady-state, the time constant, a simple simulation
using a somatic current injection, and a family of curves
generated modeling the same protocol used in the experiments. 

Markers show the time constants reported in Fig.1c' of the paper.
 
By reducing the ghbar parameter to 0
one can model the Ih block by Cesium as in Fig.1a'.
 
Under unix systems:
to compile the mod files use the command 
nrnivmodl 
and run the simulation hoc file with the command 
nrngui kinetics.hoc

Under Windows using NEURON 5.2:
to compile the mod files use the "mknrndll" command.
A double click on the simulation file
kinetics.hoc 
will open the simulation window.

Questions on how to use this model should be directed to
michele.migliore@pa.ibf.cnr.it

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