Pyramidal Neuron Deep: attenuation in dendrites (Stuart, Spruston 1998)

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Accession:3677
Stuart, G. and Spruston, N. Determinants of voltage attenuation in neocortical pyramidal neuron dendrites. Journal of Neuroscience 18:3501-3510, 1998.
Reference:
1 . Stuart G, Spruston N (1998) Determinants of voltage attenuation in neocortical pyramidal neuron dendrites. J Neurosci 18:3501-10 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Neocortex L5/6 pyramidal GLU cell;
Channel(s): I h;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Parameter Fitting;
Implementer(s): Spruston, Nelson [Spruston at Northwestern.edu];
Search NeuronDB for information about:  Neocortex L5/6 pyramidal GLU cell; I h;
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spru1998
Ri18
Ri21
Ri22
Readme
iqq.mod
synampa.mod
mosinit.hoc
                            
TITLE Q current

UNITS {
	(mA) = (milliamp)
	(mV) = (millivolt)
        (mM) = (milli/liter)

}

INDEPENDENT {t FROM 0 TO 1 WITH 1 (ms)}

PARAMETER {
	dt (ms)
	v (mV)
	erevq=-35    (mV)
	celsius = 30 (degC)
	gqbar=.003   (mho/cm2)
	vhalf=-88    (mV)
	a0=0.00057   (/ms)
	b0=0.00057   (/ms)
	zeta=3       (1)
	gq=0.4       (1)
	qten=5	     (1)
}


NEURON {
	SUFFIX qq
	NONSPECIFIC_CURRENT Iqq
	RANGE Iqq,gqbar
	GLOBAL inf,tau
}

STATE {
	qq
}

ASSIGNED {
	Iqq (mA/cm2)
	inf
	tau
}

INITIAL {
	rate(v)
	qq=inf
}

BREAKPOINT {
	SOLVE state
	Iqq = gqbar*qq*(v-erevq)

}

FUNCTION alp(v(mV)) {
	alp = exp( 1.e-3*zeta*(v-vhalf)*9.648e4/(8.315*(273.16+celsius)))
}

FUNCTION bet(v(mV)) {
	bet = exp(1.e-3*zeta*gq*(v-vhalf)*9.648e4/(8.315*(273.16+celsius))) 
}

LOCAL facq

:if state_borgka is called from hoc, garbage or segmentation violation will
:result because range variables won't have correct pointer.  This is because
: only BREAKPOINT sets up the correct pointers to range variables.
PROCEDURE state() {     : exact when v held constant; integrates over dt step
	rate(v)
	qq = qq + facq*(inf - qq)
	VERBATIM
	return 0;
	ENDVERBATIM
}

PROCEDURE rate(v (mV)) { :callable from hoc
	LOCAL a,q10
	q10=qten^((celsius-23)/10)
	a = alp(v)
	inf = 1/(1 + a)
	tau = bet(v)/(q10*(a0+b0*a))
	if (tau<2) {tau=10}
	facq = (1 - exp(-dt/tau))^1.2
}















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