Cardiac Atrial Cell (Courtemanche et al 1998)

 Download zip file   Auto-launch 
Help downloading and running models
Accession:3800
Marc Courtemanche, Rafael J. Ramirez, and Stanley Nattel. Ionic mechanisms underlying human atrial action potential properties insights from a mathematical model Am J Physiol Heart Circ Physiol 1998 275: H301-H321. The implementation of this model in NEURON was contributed by Ingemar Jacobson.
Reference:
1 . Courtemanche M, Ramirez RJ, Nattel S (1998) Ionic mechanisms underlying human atrial action potential properties: insights from a mathematical model. Am J Physiol 275:H301-21 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Cardiac atrial cell; Heart cell;
Channel(s): I Na,t; I L high threshold; I K; I Sodium; I Calcium; I Potassium; Na/Ca exchanger;
Gap Junctions:
Receptor(s):
Gene(s): Kv4.3 KCND3; Kv1.5 KCNA5; HERG KCNH2;
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Ion Channel Kinetics; Action Potentials; Heart disease; Calcium dynamics;
Implementer(s): Jacobson, Ingemar [Ingemar.Jacobson at astrazeneca.com];
Search NeuronDB for information about:  I Na,t; I L high threshold; I K; I Sodium; I Calcium; I Potassium; Na/Ca exchanger;
COMMENT
	calcium accumulation into NSR, taken from from Courtemanche et al Am J Physiol 1998 275:H301
ENDCOMMENT

NEURON {
	SUFFIX ca_nsracc
	USEION cu READ cui WRITE cui VALENCE 2 : calcium ion in nsr
	USEION cr READ  cri  VALENCE 2 : calcium ion in jsr
	USEION ca READ cai
	RANGE Vrel, Vup, Iupmax, Kup, cupmax
}

UNITS {
	(mM) = (milli/liter)
	(mA) = (milliamp)
	
}
ASSIGNED{
	cri 			(mM)
	cai 			(mM)
}
PARAMETER {
	Vrel =  96.48e-12     	(cm3)
	Vup = 1109.52e-12  	(cm3) 
	Kup = 0.00092          	(mM) 
	Iupmax = 0.005   	(mM/ms)
	cupmax = 15		(Mm)
	
	
}

STATE {
	cui START 1.5	(mM)
}

INITIAL {
	VERBATIM
	cui = _ion_cui;
	
	ENDVERBATIM
}

BREAKPOINT {
	SOLVE state METHOD derivimplicit
}

DERIVATIVE state {
	cui' = Iupmax/(1 + (Kup/cai)) - cui*Iupmax/cupmax - (cui - cri)/180*Vrel/Vup
}

Loading data, please wait...