Cardiac Atrial Cell (Courtemanche et al 1998)

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Accession:3800
Marc Courtemanche, Rafael J. Ramirez, and Stanley Nattel. Ionic mechanisms underlying human atrial action potential properties insights from a mathematical model Am J Physiol Heart Circ Physiol 1998 275: H301-H321. The implementation of this model in NEURON was contributed by Ingemar Jacobson.
Reference:
1 . Courtemanche M, Ramirez RJ, Nattel S (1998) Ionic mechanisms underlying human atrial action potential properties: insights from a mathematical model. Am J Physiol 275:H301-21 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Cardiac atrial cell; Heart cell;
Channel(s): I Na,t; I L high threshold; I K; I Sodium; I Calcium; I Potassium; Na/Ca exchanger;
Gap Junctions:
Receptor(s):
Gene(s): Kv4.3 KCND3; Kv1.5 KCNA5; HERG KCNH2;
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Ion Channel Kinetics; Action Potentials; Heart disease; Calcium dynamics;
Implementer(s): Jacobson, Ingemar [Ingemar.Jacobson at astrazeneca.com];
Search NeuronDB for information about:  I Na,t; I L high threshold; I K; I Sodium; I Calcium; I Potassium; Na/Ca exchanger;
TITLE Sodium ion accumulation
: Intracellular sodium ion accumulation 

NEURON {
	SUFFIX Na_acc
	USEION na READ ina,nai WRITE nai
	RANGE Vi, Naneutral : electroneutral sodium accumulation
}

UNITS {
	
	(mV) = (millivolt)
	(um) = (micron)
	(mM) = (milli/liter)
	(mA) = (milliamp)
	F = (faraday) (coulombs)
}

PARAMETER {
	Naneutral   =  3e-5    (mA/cm2)   <0,1e6>
	Vi = 13668e-12 (cm3)
	ina		(mA/cm2)
	
          
}

STATE {
	nai START 9.19	(mM)
	
}

LOCAL ViF
INITIAL {
	VERBATIM

	nai = _ion_nai;
	
	ENDVERBATIM
	ViF = F*Vi*2e4
}

BREAKPOINT {
	SOLVE state METHOD derivimplicit
}

DERIVATIVE state {
	nai' = -(ina-Naneutral)/(ViF) 
}
	


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