Leech Mechanosensory Neurons: Synaptic Facilitation by Reflected APs (Baccus 1998)

 Download zip file   Auto-launch 
Help downloading and running models
This model by Stephen Baccus explores the phenomena of action potential (AP) propagation at branch boints in axons. APs are sometimes transmitted down the efferent processes and sometimes are reflected back to the axon of AP origin or neither. See the paper for details. The model zip file contains a readme.txt which list introductory steps to follow to run the simulation. Stephen Baccus's email address: baccus@fas.harvard.edu
1 . Baccus SA (1998) Synaptic facilitation by reflected action potentials: enhancement of transmission when nerve impulses reverse direction at axon branch points. Proc Natl Acad Sci U S A 95:8345-50 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Leech pressure (P) mechanosensory neuron;
Channel(s): I K; I K,Ca; I Sodium; I Calcium; I Potassium;
Gap Junctions:
Simulation Environment: NEURON;
Model Concept(s): Action Potential Initiation; Pattern Recognition; Activity Patterns; Spatio-temporal Activity Patterns; Influence of Dendritic Geometry; Detailed Neuronal Models; Synaptic Plasticity; Short-term Synaptic Plasticity; Axonal Action Potentials; Action Potentials; Facilitation; Invertebrate;
Implementer(s): Baccus, Stephen [Baccus at fas.Harvard.edu];
Search NeuronDB for information about:  I K; I K,Ca; I Sodium; I Calcium; I Potassium;
TITLE caacum.mod: Calcium ion accumulation   
NEURON {       
   SUFFIX ca       
   USEION ca READ ica, cai WRITE cai 
INDEPENDENT {t FROM 0 TO 1 WITH 10 (ms)}       
UNITS {       
   (molar) = (1/liter)       
   (mV) = (millivolt)       
   (um) = (micron)       
   (mM) = (millimolar)       
   (mA) = (milliamp)       
   FARADAY = 96520 (coul)       
   R = 8.3134     (joule/degC)       
PARAMETER {       
   celsius=20     (degC)       
   cabath = 1.8   (mM)       
   diam = 1 (um)       
   ica            (mA/cm2)       
STATE {       
INITIAL {       
   cai = 0.0001;
   SOLVE state METHOD derivimplicit
DERIVATIVE state {       
   cai' = -ica * 4/(diam*FARADAY) * (1e4)  
This model uses ica but does not WRITE it; thus this model does       
not add anything to the total ionic current.       
The initial block works around a difficulty that arises from a STATE in      

this model having the same name as an ion.  (Note: in the cabpump model      

there is no name conflict between the ca[] states and the cai ion       
concentration.) The sequence of events when finitialize is called is       
that the ca_ion's cai is initialized to the global variables       
cai0_ca_ion. Then this model's INITIAL block      
is called. By default, cai/cao would be set to the initial state values      

cai0/cao0 implicitly declared in this model and on exit from the intitial    

block, the ca_ion values would be assigned these local values. We therefore  

directly set the local state values to the ca_ion values. See the       
"nocmodl cacum" generated caacum.c file to see the precise sequence on       
the nrn_init() call.       
diam is a special range variable in NEURON and refers to the diameter in     

microns.  Under scop and hocmodl its default value is specified in the       
PARAMETER block. In NEURON, however, its value is taken from the       
"morphology" mechanism.       

Loading data, please wait...