Bursting activity of neuron R15 in Aplysia (Canavier et al 1991, Butera et al 1995)

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Accession:42323
An equivalent circuit model of the R15 bursting neuron in Aplysia has been combined with a fluid compartment model, resulting in a model that incorporates descriptions of most of the membrane ion channels that are known to exist in the somata of R15, as well as providing a Ca2+ balance on the cell. ... (from the second paper) we have implemented proposed mechanisms for the modulation of two ionic currents (IR and ISI) that play key roles in regulating its spontaneous electrical activity. The model was sufficient to simulate a wide range of endogenous activity in the presence of various concentrations of 5-HT or DA. See papers for more and details.
References:
1 . Butera RJ, Clark JW, Canavier CC, Baxter DA, Byrne JH (1995) Analysis of the effects of modulatory agents on a modeled bursting neuron: dynamic interactions between voltage and calcium dependent systems. J Comput Neurosci 2:19-44 [PubMed]
2 . Canavier CC, Clark JW, Byrne JH (1991) Simulation of the bursting activity of neuron R15 in Aplysia: role of ionic currents, calcium balance, and modulatory transmitters. J Neurophysiol 66:2107-24 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Aplysia R15 bursting neuron;
Channel(s): I Na,t; I N; I K; I h; I Calcium;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: SNNAP;
Model Concept(s): Bursting; Oscillations; Invertebrate;
Implementer(s): Baxter, Douglas;
Search NeuronDB for information about:  I Na,t; I N; I K; I h; I Calcium;
README_R15.txt

The goal of the present simulation is to 
illustrate how SNNAP can be used to simulation
the biophysical properties of a relatively
complex neuron. 

The R15 model is based on models originally
published by Canavier et al. (1991) and 
Butera et al. 1995: 

Butera, R.J., Clark, J.W., Canavier, C.C., 
Baxter, D.A., and Byrne, J.H.  (1995)
Analysis of the effects of modulatory agents
on a modeled bursting neuron: dynamic
interations between voltage and calcium
dependent systems.  J. Comput. Neurosci.
2: 19-44.

Canavier, C.C., Clark, J.W. and Byrne, J.H.
(1991)  Simulation of the bursting activity
of neuron R15 in Aplysia: role of ionic
currents, calcium balance, and modulatory 
transmitters.  J. Neurophysiol. 66: 2107-2124.

The components of the R15 neuron are illustrated
in R15_neu.jpg and Butera_model.jpg. 
The model contains eight ionic conductances,
an intracellular pool of calcium (i.e.,
Ca.ion), an intracellular pool of second messenger
(i.e., cAMP.sm), and modulatory interactions from
the ion and second messenger pools and the
membrane conductances.

The results of the default simulation are illustrated
in R15_ous.jpg.  The model produces endogenous
bursting activity.  At time=60sec a modulator
is applies via the treatment file (i.e., R15.trt).
The resultant increase in the second messenger and 
modulation of membrane conductances alters the 
electrical activity of the neuron.



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