CA1 pyramidal neuron: dendritic spike initiation (Gasparini et al 2004)

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Accession:44050
NEURON mod files from the paper: Sonia Gasparini, Michele Migliore, and Jeffrey C. Magee On the initiation and propagation of dendritic spikes in CA1 pyramidal neurons, J. Neurosci., J. Neurosci. 24:11046-11056 (2004).
Reference:
1 . Gasparini S, Migliore M, Magee JC (2004) On the initiation and propagation of dendritic spikes in CA1 pyramidal neurons. J Neurosci 24:11046-11056 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Dendrite;
Brain Region(s)/Organism:
Cell Type(s): Hippocampus CA1 pyramidal cell;
Channel(s): I Na,t; I A; I K; I h;
Gap Junctions:
Receptor(s): AMPA; NMDA;
Gene(s):
Transmitter(s): Glutamate;
Simulation Environment: NEURON;
Model Concept(s): Action Potential Initiation; Dendritic Action Potentials; Coincidence Detection; Active Dendrites; Detailed Neuronal Models; Action Potentials;
Implementer(s): Migliore, Michele [Michele.Migliore at Yale.edu];
Search NeuronDB for information about:  Hippocampus CA1 pyramidal cell; AMPA; NMDA; I Na,t; I A; I K; I h; Glutamate;
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gaspiriniEtAl2004
readme.txt *
exp2i.mod *
h.mod *
kadist.mod *
kaprox.mod *
kdrca1.mod *
na3s.mod *
naxn.mod *
netstims.mod *
nmdanet.mod *
forfig5A.hoc *
mosinit.hoc *
n160.nrn *
                            
NEURON mod files from the paper:
Sonia Gasparini, Michele Migliore, and Jeffrey C. Magee
On the initiation and propagation of dendritic spikes in CA1 pyramidal neurons,
J.Neurosci. 24:11046-11056 (2004).

The paper investigates the dendritic spike probability as a function 
of the number of activated synaptic input and their spatial and temporal distribution.
The results suggest that highly synchronized and moderately clustered inputs 
have the highest probability to generate a dendritic spike.

The main effect is demonstrated here by reproducing the simulations
in Fig.5A of the paper, in which 5 synapses were activated 
in the same compartment with different time delays.
Simulations can be run for different kind of synaptic input:
- current pulses 
- AMPA 
- AMPA+NMDA

Under unix systems:
to compile the mod files use the command 
nrnivmodl 
and run the simulation hoc file with the command 
nrngui forfig5A.hoc

Under Windows systems:
to compile the mod files use the "mknrndll" command.
A double click on the simulation file
forfig5A.hoc 
will open the simulation window.

Questions on how to use this model
should be directed to michele.migliore@pa.ibf.cnr.it



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