Kinetic NMDA receptor model (Kampa et al 2004)

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Accession:50207
This kinetic NMDA receptor model is based on voltage-clamp recordings of NMDA receptor-mediated currents in nucleated patches of rat neocortical layer 5 pyramidal neurons (Kampa et al 2004 J Physiol), this model was fit with AxoGraph directly to experimental recordings in order to obtain the optimal values for the parameters. The demo shows the behaviour of a kinetic NMDA receptor model reproducing the data in figure 2. The NMDA receptor model uses realistic rates of magnesium block and its effects on channel desensitisation. Presynaptic transmitter release is necessary for glutamate binding to the receptor. This model was written by Bjoern Kampa, Canberra, 2004.
Reference:
1 . Kampa BM, Clements J, Jonas P, Stuart GJ (2004) Kinetics of Mg2+ unblock of NMDA receptors: implications for spike-timing dependent synaptic plasticity. J Physiol 556:337-45 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Synapse;
Brain Region(s)/Organism:
Cell Type(s): Neocortex V1 pyramidal corticothalamic L6 cell;
Channel(s):
Gap Junctions:
Receptor(s): NMDA; Glutamate;
Gene(s):
Transmitter(s): Glutamate;
Simulation Environment: NEURON;
Model Concept(s): Ion Channel Kinetics; Synaptic Plasticity; Long-term Synaptic Plasticity;
Implementer(s): Kampa, Bjorn M [Bjoern.Kampa at anu.edu.au];
Search NeuronDB for information about:  Neocortex V1 pyramidal corticothalamic L6 cell; NMDA; Glutamate; Glutamate;
Kinetic NMDA receptor model
---------------------------

Based on voltage-clamp recordings of NMDA receptor-mediated currents in 
nucleated patches of  rat neocortical layer 5 pyramidal neurons (Kampa 2004),
this model was fit with AxoGraph directly to experimental recordings in order
to obtain the optimal values for the parameters.
------------------------------------------------------

Demo file shows the behaviour of a kinetic NMDA receptor model reproducing the 
data in figure 2 in Kampa et al (2004) J Physiol.
------------------------------------------------------

The NMDA receptor model uses realistic rates of magnesium block and its effects 
on channel desensitisation. Presynaptic transmitter release is necessary for 
glutamate binding to the receptor. 
------------------------------------------------------

Kinetic model from Kampa et al (2004) Kinetics of Mg2+ unblock of NMDA 
receptors: implications for spike-timing dependent synaptic plasticity. 
In: J Physiol 556.2: pp 337–345.
--------------------------------
Model written by Bjoern Kampa, Canberra, 2004 


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