Fast oscillations in inhibitory networks (Maex, De Schutter 2003)

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We observed a new phenomenon of resonant synchronization in computer-simulated networks of inhibitory neurons in which the synaptic current has a delayed onset, reflecting finite spike propagation and synaptic transmission times. At the resonant level of network excitation, all neurons fire synchronously and rhythmically with a period approximately four times the mean delay of the onset of the inhibitory synaptic current. ... By varying the axonal delay of the inhibitory connections, networks with a realistic synaptic kinetics can be tuned to frequencies from 40 to >200 Hz. ... We conclude that the delay of the synaptic current is the primary parameter controlling the oscillation frequency of inhibitory networks and propose that delay-induced synchronization is a mechanism for fast brain rhythms that depend on intact inhibitory synaptic transmission.
1 . Maex R, De Schutter E (2003) Resonant Synchronization in Heterogeneous Networks of Inhibitory Neurons. J Neurosci 23:10503-10514 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism: Generic;
Cell Type(s): Cerebellum interneuron granule cell;
Channel(s): I Na,t; I L high threshold; I A; I K; I h; I K,Ca;
Gap Junctions:
Receptor(s): GabaA; AMPA;
Simulation Environment: GENESIS (web link to model);
Model Concept(s): Oscillations; Synchronization; Simplified Models;
Implementer(s): Maex, Reinoud [reinoud at];
Search NeuronDB for information about:  Cerebellum interneuron granule cell; GabaA; AMPA; I Na,t; I L high threshold; I A; I K; I h; I K,Ca;
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