Role of KCNQ1 and IKs in cardiac repolarization (Silva, Rudy 2005)


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Accession:55748
Detailed Markov models of IKs (the slow delayed rectifier K+ current) and its alpha-subunit KCNQ1 were developed. The model is compared to experiment in the paper. The role of IKs in disease and drug treatments is elucidated (the prevention of excessive action potential prolongation and development of arrhythmogenic early afterdepolarizations). See paper for more and details.
Reference:
1 . Silva J, Rudy Y (2005) Subunit interaction determines IKs participation in cardiac repolarization and repolarization reserve. Circulation 112:1384-91 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Channel/Receptor;
Brain Region(s)/Organism:
Cell Type(s):
Channel(s): I K; KCNQ1; I_Ks;
Gap Junctions:
Receptor(s):
Gene(s): Kv1.9 Kv7.1 KCNQ1;
Transmitter(s):
Simulation Environment: MATLAB (web link to model);
Model Concept(s): Activity Patterns; Ion Channel Kinetics; Action Potentials; Heart disease; Long-QT;
Implementer(s): Silva, Jonathan [jonsilva at gmail.com];
Search NeuronDB for information about:  I K; KCNQ1; I_Ks;
(located via links below)
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