Breakdown of accmmodation in nerve: a possible role for INAp (Hennings et al 2005)

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Accession:55749
The present modeling study suggests that persistent, low-threshold, rapidly activating sodium currents have a key role in breakdown of accommodation, and that breakdown of accommodation can be used as a tool for studying persistent sodium current under normal and pathological conditions. See paper for more and details.
Reference:
1 . Hennings K, Arendt-Nielsen L, Andersen OK (2005) Breakdown of accommodation in nerve: a possible role for persistent sodium current. Theor Biol Med Model 2:16 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Spinal cord lumbar motor neuron alpha ACh cell; Myelinated neuron;
Channel(s): I Na,p; I Na,t; I K;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: MATLAB;
Model Concept(s): Action Potential Initiation; Action Potentials; Pathophysiology; Electrotonus;
Implementer(s): Hennings, Kristian [krist at hst.auc.dk];
Search NeuronDB for information about:  Spinal cord lumbar motor neuron alpha ACh cell; I Na,p; I Na,t; I K;
function [E0p,E0,E] = prepulseTp(Type,P,Tp,Ts,M)
%PREPULSET Estimate the effect of prepulses, where the prepulse duration is changed
%   [E0p,E0,E] = prepulseTp(Type,P,Tp,Ts,M)

Imax = 10e-9; Nmsi = 10; Itol = 0.0001e-9; noAP = 1; 
MSAVE = M;

Spls = pulse(0,Ts); Spls = setDC(Spls,0);
E0 = excitation(Imax,Nmsi,Itol,noAP,[0 Ts+1e-3],M,Spls);        

for k = 1:length(P)
    
    for j = 1:length(Tp)
        M = MSAVE;
        if Type == 1 
            Sp = pulse(0,Tp(j)); Sp = setDC(Sp,0);
        else
            Sp = ramp(0,Tp(j)); Sp = setDC(Sp,0);      
        end
        E0p(j) = excitation(Imax,Nmsi,Itol,noAP,[0 Tp(n)+1e-3],M,Sp);
        if Type == 1 
            Sp = pulse(-P*E0p(j),Tp(j)); Sp = setDC(Sp,0);
        else
            Sp = ramp(-P*E0p(j),Tp(j)); Sp = setDC(Sp,0);      
        end   
        M.X0 = x0patch([0 Tp(j)],Sp,M); 
        E(j) = excitation(Imax,Nmsi,Itol,noAP,[0 Ts+1e-3],M,Spls);        
    end
end
   
   
   
    
    

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