Breakdown of accmmodation in nerve: a possible role for INAp (Hennings et al 2005)

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Accession:55749
The present modeling study suggests that persistent, low-threshold, rapidly activating sodium currents have a key role in breakdown of accommodation, and that breakdown of accommodation can be used as a tool for studying persistent sodium current under normal and pathological conditions. See paper for more and details.
Reference:
1 . Hennings K, Arendt-Nielsen L, Andersen OK (2005) Breakdown of accommodation in nerve: a possible role for persistent sodium current. Theor Biol Med Model 2:16 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Spinal cord lumbar motor neuron alpha ACh cell; Myelinated neuron;
Channel(s): I Na,p; I Na,t; I K;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: MATLAB;
Model Concept(s): Action Potential Initiation; Action Potentials; Pathophysiology; Electrotonus;
Implementer(s): Hennings, Kristian [krist at hst.auc.dk];
Search NeuronDB for information about:  Spinal cord lumbar motor neuron alpha ACh cell; I Na,p; I Na,t; I K;
TE1 = 40*[0 0 4.9 6.1  7.0  7.2   7.2 7.1   7.0  6.7   6.55 6.4 6.2 6.1 6.0 5.95 5.9 5.75 5.7 0.6  0    -0.4 -0.5 -0.6 -0.5 -0.4 -0.3 -0.2]/4.7;
TE2 = 40*[0 0 4.1 4.9  5.6  5.8   5.6 5.5   5.3  5.1   4.9  4.8 4.7 4.6 4.5 4.5  4.5 4.4  4.4 -0.8 -1.5 -1.7 -1.8 -1.9 -1.9 -1.8 -1.7 -1.6]/4.7;
TS  =    [-10 0 0   6.25 12.5 18.75 25  31.25 37.5 43.75 50 56.25   62.5 68.75   75   81.25   87.5   93.75  100 100 106.2500  112.5000  118.7500 125.0000  131.2500  137.5000  143.7500  150.0000];
 
plot(TS,TE1,'k:',...
     TS,TE2,'k:');
 
 DATA = [TS' TE1' TE2'];
 save te_valid.txt DATA -ASCII

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