Breakdown of accmmodation in nerve: a possible role for INAp (Hennings et al 2005)

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Accession:55749
The present modeling study suggests that persistent, low-threshold, rapidly activating sodium currents have a key role in breakdown of accommodation, and that breakdown of accommodation can be used as a tool for studying persistent sodium current under normal and pathological conditions. See paper for more and details.
Reference:
1 . Hennings K, Arendt-Nielsen L, Andersen OK (2005) Breakdown of accommodation in nerve: a possible role for persistent sodium current. Theor Biol Med Model 2:16 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Spinal cord lumbar motor neuron alpha ACh cell; Myelinated neuron;
Channel(s): I Na,p; I Na,t; I K;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: MATLAB;
Model Concept(s): Action Potential Initiation; Action Potentials; Pathophysiology; Electrotonus;
Implementer(s): Hennings, Kristian [krist at hst.auc.dk];
Search NeuronDB for information about:  Spinal cord lumbar motor neuron alpha ACh cell; I Na,p; I Na,t; I K;
t0 = 0;
t1 = 120e-3;
h = 1e-6;
Fs = 20;
EarlyStop = 0;
save = 0;

Is = -0.5e-9;
Ts = 48.5e-3;
TAU = 48.5e-3;
Ip = -0.4e-9;
Tp = 100e-3;
Td = 20e-3;

P = parameters(t0,t1,h,Fs,EarlyStop,save);
%S = cpulse(Is,Ts,Td,Ip,Tp);
S = expr(Is,Ts);
M = defPatch(14);

TD = [20 40]*1e-3;
TS = [1 5 10 25 50 100]*1e-3;
P = [0.4];
tic
%[R,T,ts,i] = SDstat(M);
%[AC,E] = slope(M,TAU,R);
%[A,S,E] = acurve(M,TS,R);
%[X0] = x0patch([t0 t1],S,M)
%[E,E0,T,V] = te(M,TD,P);
%[APs,t,En,Ei,Is,Xn,Xi,In,Ii] = resp([t0 t1],25,M,S);
T = testm(M);
time = toc
fprintf('Time: %.2fms\n',(time)*1e3);
%plotTest(T);
% plot(TS,A);

% figure(1);
% plot(TD,-100*(E-E0)/E0,'b');
% APs
% figure(1);
% plot(t,En,'b',t,Ei,'r');
%figure(2);
%plot(t,-Is);

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