Breakdown of accmmodation in nerve: a possible role for INAp (Hennings et al 2005)

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Accession:55749
The present modeling study suggests that persistent, low-threshold, rapidly activating sodium currents have a key role in breakdown of accommodation, and that breakdown of accommodation can be used as a tool for studying persistent sodium current under normal and pathological conditions. See paper for more and details.
Reference:
1 . Hennings K, Arendt-Nielsen L, Andersen OK (2005) Breakdown of accommodation in nerve: a possible role for persistent sodium current. Theor Biol Med Model 2:16 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Spinal cord lumbar motor neuron alpha ACh cell; Myelinated neuron;
Channel(s): I Na,p; I Na,t; I K;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: MATLAB;
Model Concept(s): Action Potential Initiation; Action Potentials; Pathophysiology; Electrotonus;
Implementer(s): Hennings, Kristian [krist at hst.auc.dk];
Search NeuronDB for information about:  Spinal cord lumbar motor neuron alpha ACh cell; I Na,p; I Na,t; I K;
%TEST The function for determining the recovery cycle

Tisi = [1 1.5 2 3 4 5 6 7 8 9 10 20 30 40 50 60 70 100 200]*1e-3;
load model2_x
M = defPatch2(X);
[E,E0] = recovery(Tisi,M,0);

Tre1 = 100*[NaN NaN NaN -2.2 -3.5 -3.7 -3.85 -3.7 -3.5  -3.25 -2.9 -0.75 0.3 0.55 0.65 0.6 0.4 -0.15 -0.35]/9.9;
Tre2 = 100*[NaN NaN NaN 3.9  0   -1.2 -1.45 -1.3  -1.1 -0.8  -0.5 1.1   2   2.4  2.45 2.3 2.1  1.2   0.35]/9.9;
Tre = (Tre1+Tre2)/2;

figure(1);
plot(Tisi,100*(E-E0)/E0,'k',...
     Tisi,Tre,'b',...
     Tisi,Tre1,'b:',...
     Tisi,Tre2,'b:');

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