Breakdown of accmmodation in nerve: a possible role for INAp (Hennings et al 2005)

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Accession:55749
The present modeling study suggests that persistent, low-threshold, rapidly activating sodium currents have a key role in breakdown of accommodation, and that breakdown of accommodation can be used as a tool for studying persistent sodium current under normal and pathological conditions. See paper for more and details.
Reference:
1 . Hennings K, Arendt-Nielsen L, Andersen OK (2005) Breakdown of accommodation in nerve: a possible role for persistent sodium current. Theor Biol Med Model 2:16 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Spinal cord lumbar motor neuron alpha ACh cell; Myelinated neuron;
Channel(s): I Na,p; I Na,t; I K;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: MATLAB;
Model Concept(s): Action Potential Initiation; Action Potentials; Pathophysiology; Electrotonus;
Implementer(s): Hennings, Kristian [krist at hst.auc.dk];
Search NeuronDB for information about:  Spinal cord lumbar motor neuron alpha ACh cell; I Na,p; I Na,t; I K;
function [t,En,E0] = testresp(tspan,M)
%TESTRESP Test the response of a model
%   [t,En] = testresp(M)
Ts = 0.1e-3;


Imax = 10e-9; Nmsi = 5; Itol = 0.01e-9; noAP = 1; 
E0 = excitation(Imax,Nmsi,Itol,noAP,[0 1e-3],M,pulse(0,Ts));
[APs,t,En,Ei,Is,Xn,Xi,In,Ii] = resp(tspan,2,M,pulse(-E0,Ts));

fprintf('Action potentials: %d\n',APs);

figure(1);
clf;
%subplot(3,1,1);
plot(t,En,'b',t,Ei,'r',tspan*1e3,[M.X0(1) M.X0(1)]*1e3,'b:',tspan*1e3,[M.X0(2) M.X0(2)]*1e3,'r:');
legend('E_n','E_i');


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