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HERG K+ channels spike-frequency adaptation (Chiesa et al 1997)
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Spike frequency adaptation has contributions from the IHERG current (encoded by the human eag-related gene (HERG); Warmke & Ganetzky, 1994), which develops with slow kinetics during depolarization and contributes to the repolarization of the long action potentials typically present in the heart. IHERG is one of the delayed rectifier currents (IK(r)) of the heart, and HERG mutations are associated with one of the cardiac arrhythmia LQT syndromes (LQT2). See paper for more and details.
Chiesa N, Rosati B, Arcangeli A, Olivotto M, Wanke E (1997) A novel role for HERG K+ channels: spike-frequency adaptation.
501 ( Pt 2)
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Neuron or other electrically excitable cell;
Spike Frequency Adaptation;
Wu, Sheng-Nan [snwu at mail.ncku.edu.tw];
Wu, Jiun-Shian [coolneon at gmail.com];
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